Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637748 | 0.85 | PTGS2 (0.56) | PTGS2PTGS1 | |
| SCHEMBL8067283 | 0.82 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL8074136 | 0.79 | EPAS1 (0.42) | PTGS2PTGS1 | |
| SCHEMBL8069284 | 0.77 | PTGS2 (0.53) | PTGS2PTGS1 | |
| SCHEMBL3865448 | 0.76 | PTGS2 (0.40) | PTGS2CYP11B1CYP11B2CA12CA1 | |
| SCHEMBL4190362 | 0.75 | PTGS2 (0.72) | PTGS2CYP11B1CYP11B2CA12CA1 | |
| SCHEMBL8068397 | 0.75 | PTGS2 (0.53) | PTGS2 | |
| SCHEMBL8058037 | 0.74 | PTGS2 (0.57) | PTGS2PTGS1 | |
| SCHEMBL803901 | 0.73 | PTGS2 (0.68) | PTGS2CYP11B1CYP11B2CA12CA1 | |
| Isophthalic Acid SCHEMBL27322237 | 0.73 | CSNK2A1 (0.41) | PTGS2CYP11B1CYP11B2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0856000-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLES FOR TREAMENT OF INFLAMMATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-08-05 | — | — | EP | disclosed |
| WO-1997013755-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLES FOR TREAMENT OF INFLAMMATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-17 | — | — | WO | disclosed |