Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 6/20 | 0.48 |
| ▸ | PPARG | P37231 | 3/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | ACE | P12821 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639100 | 0.73 | LTA4H (0.54) | LTA4HPPARGPPARASMN1; SMN2LMNA | |
| SCHEMBL8773741 | 0.72 | LTA4H (0.52) | LTA4HL3MBTL1 | |
| SCHEMBL1894379 | 0.71 | KDM4E (0.44) | ACEALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL8635942 | 0.71 | LTA4H (0.79) | LTA4H | |
| SCHEMBL19535305 | 0.70 | LTA4H (0.60) | LTA4H | |
| SCHEMBL3635096 | 0.70 | LTA4H (0.60) | LTA4H | |
| SCHEMBL21241445 | 0.70 | ACE (0.45) | LTA4HACEALDH1A1SMN1; SMN2 | |
| SCHEMBL7250988 | 0.70 | CHRNB4 (0.41) | — | |
| SCHEMBL7138655 | 0.70 | LTA4H (0.71) | LTA4HALDH1A1SMN1; SMN2HRH3LMNA | |
| SCHEMBL8635939 | 0.69 | LTA4H (0.60) | LTA4HALDH1A1SMN1; SMN2HRH3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |