Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.53 |
| ▸ | DRD4 | P21917 | 3/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8643772 | 0.99 | HTR1A (0.51) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL8648451 | 0.91 | HTR1A (0.55) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL8648288 | 0.90 | HTR1A (0.54) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL8651533 | 0.82 | HTR1A (0.57) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL8644809 | 0.81 | HTR1A (0.52) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL8646293 | 0.80 | HTR1A (0.53) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL6312480 | 0.80 | HTR1A (0.62) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| Cyclohexane SCHEMBL8646429 | 0.80 | HTR1A (0.54) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL8647802 | 0.80 | DRD2 (0.55) | HTR1AADRA1ADRD4ADRA1DADRA1B | |
| SCHEMBL8646310 | 0.80 | HTR1A (0.52) | HTR1AADRA1ADRD4ADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690845-B1 | PIPERAZINE DERIVATIVES AS 5-HT1A LIGANDS | WYETH JOHN & BROTHER LTD (GB) | 1998-09-09 | — | — | EP | claimed |
| US-5693642-A | ANXIOLYTIC AND HYPOTENSIVE AGENTS; ANTIDEPRESSANTS; PSYCHOLOGICAL DISORDERS; CONTROLLERS OF SLEEP/WAKE CYCLE, EATING AND SEXUAL DISORDERS | JOHN WYETH & BROTHER LTD. (GB) | 1997-12-02 | — | — | US | claimed |
| EP-0690845-A1 | PIPERAZINE DERIVATIVES AS 5-HT1A LIGANDS | JOHN WYETH & BROTHER LIMITED (GB) | 1996-01-10 | — | — | EP | claimed |
| WO-1994021610-A1 | PIPERAZINE DERIVATIVES AS 5-HT1A LIGANDS | JOHN WYETH & BROTHER LIMITED (GB) | 1994-09-29 | — | — | WO | claimed |
| EP-0690845-B1 | PIPERAZINE DERIVATIVES AS 5-HT1A LIGANDS | WYETH JOHN & BROTHER LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5693642-A | ANXIOLYTIC AND HYPOTENSIVE AGENTS; ANTIDEPRESSANTS; PSYCHOLOGICAL DISORDERS; CONTROLLERS OF SLEEP/WAKE CYCLE, EATING AND SEXUAL DISORDERS | JOHN WYETH & BROTHER LTD. (GB) | 1997-12-02 | — | — | US | disclosed |