Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.41 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 3/20 | 0.40 |
| ▸ | MMEL1 | Q495T6 | 2/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 3/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8640412 | 0.92 | REN (0.46) | RENMMEACELMNA | |
| SCHEMBL8639909 | 0.88 | REN (0.43) | RENMMEACELMNA | |
| SCHEMBL8638062 | 0.88 | REN (0.42) | RENMMEACELMNA | |
| SCHEMBL8644979 | 0.88 | REN (0.42) | RENMMEACELMNA | |
| SCHEMBL8641863 | 0.86 | MME (0.49) | ERAP2ERAP1LNPEPMMEMMEL1 | |
| SCHEMBL8756920 | 0.86 | REN (0.47) | RENMMEACELMNA | |
| SCHEMBL8638508 | 0.85 | NPC1 (0.39) | RENMMEACE | |
| SCHEMBL8642399 | 0.85 | NPC1 (0.39) | RENMMEACE | |
| SCHEMBL8636757 | 0.84 | MME (0.50) | MMEACELMNAF10F2 | |
| SCHEMBL8639879 | 0.81 | ACE (0.42) | MMEACELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0766694-B1 | PEPTIDE DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 1998-08-05 | — | — | EP | disclosed |