Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552358 | 0.79 | GLS (0.46) | PTPN2PTPN1PTPN6SMN1; SMN2NPC1 | |
| SCHEMBL16457485 | 0.75 | KDM4E (0.49) | SMN1; SMN2JAK1LMNADDB1CRBN | |
| SCHEMBL16457551 | 0.74 | KDM4E (0.49) | JAK1DDB1CRBNKDM4EMAPT | |
| SCHEMBL27986654 | 0.74 | KDM4E (0.48) | SMN1; SMN2JAK1DDB1CRBNKDM4E | |
| SCHEMBL8624453 | 0.74 | KDM4E (0.48) | PTPN2PTPN1PTPN6JAK1DDB1 | |
| SCHEMBL16457261 | 0.74 | KDM4E (0.48) | SMN1; SMN2JAK1LMNADDB1CRBN | |
| SCHEMBL8625113 | 0.74 | KDM4E (0.40) | JAK1DDB1CRBNKDM4EMAPT | |
| SCHEMBL2512441 | 0.73 | KDM4E (0.52) | PTPN2PTPN1PTPN6JAK1DDB1 | |
| SCHEMBL16457698 | 0.73 | KDM4E (0.49) | NPC1RAB9AJAK1DDB1CRBN | |
| SCHEMBL8550947 | 0.72 | KDM4E (0.51) | PTPN2PTPN1PTPN6JAK1DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858457-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | Dr. Karl Thomae GmbH (DE) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997015567-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | DR. KARL THOMAE GMBH (DE) | 1997-05-01 | — | — | WO | disclosed |