Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 3/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8553616 | 0.83 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL8553647 | 0.82 | LMNA (0.43) | — | |
| SCHEMBL8645650 | 0.79 | PTPN2 (0.46) | PTPN2PTPN1PTPN6ALDH1A1SMN1; SMN2 | |
| SCHEMBL8592851 | 0.75 | CYP2C9 (0.45) | GLSALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL8553949 | 0.75 | LMNA (0.45) | — | |
| SCHEMBL8550488 | 0.72 | KDM4E (0.44) | GLSPTPN2PTPN1PTPN6ALDH1A1 | |
| SCHEMBL8551904 | 0.72 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL8553067 | 0.72 | GLS (0.38) | GLSALDH1A1SMN1; SMN2GPR119 | |
| SCHEMBL8590974 | 0.72 | L3MBTL1 (0.44) | MEN1KMT2A | |
| SCHEMBL5883993 | 0.72 | SMN1; SMN2 (0.48) | ALDH1A1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858457-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | Dr. Karl Thomae GmbH (DE) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997015567-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | DR. KARL THOMAE GMBH (DE) | 1997-05-01 | — | — | WO | disclosed |