Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 3/20 | 0.67 |
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.62 |
| ▸ | MMP13 | P45452 | 9/20 | 0.61 |
| ▸ | MMP2 | P08253 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | MMP14 | P50281 | 4/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1420412 | 0.99 | KDM4E (0.68) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL8548699 | 0.94 | HRH3 (0.65) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL3579275 | 0.89 | MMP13 (0.70) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL31735834 | 0.88 | ALOX15 (0.65) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL327246 | 0.88 | ALOX15 (0.65) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL3264625 | 0.87 | KDM4E (0.54) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL6517276 | 0.85 | RAB9A (0.68) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL3264118 | 0.85 | KDM4E (0.52) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL6524973 | 0.84 | KDM4E (0.67) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL1616056 | 0.83 | XDH (0.56) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832066-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL-) AMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| EP-0832065-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER INC. (US) | 1998-04-01 | — | — | EP | disclosed |