Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.54 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8648675 | 0.90 | MTNR1A (0.55) | LMNACYP1A2CYP2C9TSHRNPSR1 | |
| SCHEMBL8649352 | 0.85 | PLA2G2A (0.70) | LMNACYP1A2CYP2C9TSHRNPSR1 | |
| SCHEMBL8649350 | 0.78 | AKR1C2 (0.67) | LMNACYP1A2CYP2C9TSHRNPSR1 | |
| SCHEMBL8645716 | 0.77 | PLA2G2A (0.59) | PLA2G2APLA2G1BNTRK1 | |
| SCHEMBL18271503 | 0.76 | PLA2G2A (0.56) | LMNACYP1A2CYP2C9TSHRNPSR1 | |
| SCHEMBL8367147 | 0.75 | AKR1C2 (0.58) | LMNACYP1A2CYP2C9TSHRNPSR1 | |
| SCHEMBL9017563 | 0.75 | MTNR1A (0.44) | NPSR1PLA2G2AMTNR1AMTNR1BKDM4E | |
| SCHEMBL8292246 | 0.73 | PLA2G2A (0.76) | LMNACYP1A2CYP2C9TSHRNPSR1 | |
| SCHEMBL8648559 | 0.72 | PLA2G2A (0.48) | LMNACYP1A2CYP2C9TSHRNPSR1 | |
| SCHEMBL9017573 | 0.72 | PLA2G2A (0.74) | LMNACYP1A2CYP2C9TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0746544-B1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMA INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0746544-A1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMACEUTICALS INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995022524-A1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMACEUTICALS INC. (US) | 1995-08-24 | — | — | WO | disclosed |