Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8648675 | 0.76 | MTNR1A (0.55) | MTNR1AMTNR1BNTRK1MAPTKDM4E | |
| SCHEMBL8645955 | 0.75 | LMNA (0.54) | MTNR1AMTNR1BNTRK1MAPTKDM4E | |
| SCHEMBL28426879 | 0.68 | NTRK1 (0.60) | MTNR1AMTNR1BNTRK1MAPTKDM4E | |
| SCHEMBL9177751 | 0.66 | EGFR (0.51) | NTRK1MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL8645716 | 0.64 | PLA2G2A (0.59) | NTRK1PLA2G2A | |
| SCHEMBL2687074 | 0.64 | PTGS2 (0.49) | MTNR1AMTNR1BMAPTKDM4EALDH1A1 | |
| SCHEMBL8649352 | 0.63 | PLA2G2A (0.70) | NTRK1MAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL11266493 | 0.63 | KDM4E (0.42) | MAPTKDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL17697978 | 0.62 | DRD2 (0.56) | MTNR1AMTNR1BNTRK1MAPTKDM4E | |
| SCHEMBL30863921 | 0.62 | ALDH1A1 (0.60) | NTRK1MAPTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0746544-A1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMACEUTICALS INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995022524-A1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMACEUTICALS INC. (US) | 1995-08-24 | — | — | WO | disclosed |