Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 13/20 | 0.72 |
| ▸ | HTR2A | P28223 | 5/20 | 0.57 |
| ▸ | HTR2C | P28335 | 5/20 | 0.57 |
| ▸ | DRD3 | P35462 | 3/20 | 0.54 |
| ▸ | HTR6 | P50406 | 2/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553908 | 0.79 | HTR7 (1.00) | HTR7HTR2AHTR2CDRD3HTR1A | |
| Hydrochloric Acid SCHEMBL8593597 | 0.78 | HTR7 (0.98) | HTR7HTR2AHTR2CDRD3HTR1A | |
| SCHEMBL9489271 | 0.76 | P2RX7 (0.64) | HTR7HTR2AHTR2CDRD3HTR6 | |
| SCHEMBL8552181 | 0.73 | HTR7 (0.77) | HTR7HTR2AHTR2CDRD3HTR1A | |
| SCHEMBL9488051 | 0.73 | P2RX7 (0.83) | P2RX7 | |
| SCHEMBL9484420 | 0.70 | P2RX7 (0.83) | P2RX7 | |
| SCHEMBL5247641 | 0.70 | MEN1 (0.57) | HTR7HTR6 | |
| SCHEMBL13995405 | 0.70 | SIGMAR1 (0.66) | HTR1ADRD2 | |
| SCHEMBL2952847 | 0.69 | MAPT (0.71) | HTR7HTR2AHTR6HTR1ADRD2 | |
| SCHEMBL9373661 | 0.69 | KDM4E (0.71) | HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0883613-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-12-16 | — | — | EP | disclosed |
| WO-1997029097-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-14 | — | — | WO | disclosed |