Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3525432 | 0.90 | KDM4E (0.47) | KDM4ELOXL2CYP1A2CYP2A6FFAR1 | |
| SCHEMBL866002 | 0.87 | LOXL2 (0.43) | KDM4ELOXL2FFAR1F2LMNA | |
| SCHEMBL28189651 | 0.85 | KDM4E (0.43) | KDM4ELOXL2CYP1A2CYP2A6FFAR1 | |
| SCHEMBL11710173 | 0.85 | KDM4E (0.47) | KDM4ELOXL2CYP1A2CYP2A6FFAR1 | |
| SCHEMBL864947 | 0.84 | KDM4E (0.43) | KDM4ELOXL2CYP1A2FFAR1F2 | |
| SCHEMBL865468 | 0.82 | HTR1A (0.43) | KDM4ELOXL2F2HTR1AHTR1D | |
| SCHEMBL28038688 | 0.78 | KDM4E (0.40) | KDM4ELOXL2FFAR1DAOMEN1 | |
| SCHEMBL8999779 | 0.78 | MAPT (0.57) | KDM4ECYP2A6MEN1KMT2ANPC1 | |
| SCHEMBL12829821 | 0.77 | AOC3 (0.48) | KDM4ECYP1A2CYP2A6FFAR1KIF11 | |
| SCHEMBL27542164 | 0.77 | KDM4E (0.49) | KDM4ECYP1A2CYP2A6FFAR1KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606887-A1 | DIINDOLYLMETHANE, PRECURSOR AND DERIVATIVES THEREOF IN PREPARATION OF MEDICAMENTS FOR TREATING LIVER DISEASES | Nanjing University (CN) | 2013-06-26 | — | — | EP | claimed |
| EP-2314294-A2 | 3,3'-diindolylmethane immune activating compositions | The Regents of The University of California (US) | 2011-04-27 | — | — | EP | claimed |
| US-20060100264-A1 | 3,3'-Diindolylmethane immune activating compositions | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-05-11 | — | — | US | claimed |
| EP-0971890-B1 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | TEXAS A & M UNIV SYS (US) | 2002-11-27 | — | — | EP | claimed |
| US-20020115708-A1 | Diindolylmethane and C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers | TEXAS A&M UNIVERSITY SYSTEM, THE | 2002-08-22 | — | — | US | claimed |
| EP-0971890-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2000-01-19 | — | — | EP | claimed |
| US-5948808-A | Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 1999-09-07 | — | — | US | claimed |
| WO-1998050357-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 1998-11-12 | — | — | WO | claimed |
| US-20220280479-A1 | SELF-EMULSIFYING FORMULATIONS OF DIM-RELATED INDOLES | BIORESPONSE, L.L.C. | 2022-09-08 | — | — | US | disclosed |
| US-11337961-B2 | Self-emulsifying formulations of DIM-related indoles | BIORESPONSE, L.L.C. (US) | 2022-05-24 | — | — | US | disclosed |
| US-20210046046-A1 | SELF-EMULSIFYING FORMULATIONS OF DIM-RELATED INDOLES | BIORESPONSE, L.L.C. | 2021-02-18 | — | — | US | disclosed |
| US-10799479-B2 | Self-emulsifying formulations of DIM-related indoles | BIORESPONSE, L.L.C. (US) | 2020-10-13 | — | — | US | disclosed |
| US-10441569-B2 | Self-emulsifying formulations of DIM-related indoles | BIORESPONSE, L.L.C. (US) | 2019-10-15 | — | — | US | disclosed |
| US-20180280347-A1 | SELF-EMULSIFYING FORMULATIONS OF DIM-RELATED INDOLES | BIORESPONSE, L.L.C. (US) | 2018-10-04 | — | — | US | disclosed |
| US-20040235929-A1 | Compositions containing C-substituted diindolylmethane compounds | TEXAS A&M UNIVERSITY SYSTEM, THE | 2004-11-25 | — | — | US | disclosed |
| EP-0971890-B1 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | TEXAS A & M UNIV SYS (US) | 2002-11-27 | — | — | EP | disclosed |
| US-20020115708-A1 | Diindolylmethane and C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers | TEXAS A&M UNIVERSITY SYSTEM, THE | 2002-08-22 | — | — | US | disclosed |
| EP-0971890-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2000-01-19 | — | — | EP | disclosed |
| US-5948808-A | Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 1999-09-07 | — | — | US | disclosed |
| WO-1998050357-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 1998-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220280479-A1 | SELF-EMULSIFYING FORMULATIONS OF DIM-RELATED INDOLES | IDO1, IDO2, CYP8B1 | KDM4E 1237/4885LOXL2 1610/4885CYP1A2 285/4885 |
| US-20020115708-A1 | Diindolylmethane and C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers | KRAS, VHL, TP53 | KDM4E 530/4885LOXL2 1179/4885CYP1A2 3401/4885 |
| US-10441569-B2 | Self-emulsifying formulations of DIM-related indoles | IDO1, IDO2, CYP8B1 | KDM4E 1237/4885LOXL2 1610/4885CYP1A2 285/4885 |
| US-20060100264-A1 | 3,3'-Diindolylmethane immune activating compositions | CD69, ICOS, CD14 | KDM4E 3050/4885LOXL2 2721/4885CYP1A2 1283/4885 |
| US-20210046046-A1 | SELF-EMULSIFYING FORMULATIONS OF DIM-RELATED INDOLES | IDO1, IDO2, CYP8B1 | KDM4E 1307/4885LOXL2 1229/4885CYP1A2 357/4885 |
| US-20040235929-A1 | Compositions containing C-substituted diindolylmethane compounds | KRAS, TP53, VHL | KDM4E 521/4885LOXL2 1785/4885CYP1A2 2894/4885 |
| US-11337961-B2 | Self-emulsifying formulations of DIM-related indoles | IDO1, IDO2, CYP8B1 | KDM4E 1307/4885LOXL2 1229/4885CYP1A2 357/4885 |
| US-10799479-B2 | Self-emulsifying formulations of DIM-related indoles | IDO1, IDO2, CYP8B1 | KDM4E 1307/4885LOXL2 1229/4885CYP1A2 357/4885 |
| US-20180280347-A1 | SELF-EMULSIFYING FORMULATIONS OF DIM-RELATED INDOLES | IDO1, IDO2, CYP8B1 | KDM4E 1307/4885LOXL2 1229/4885CYP1A2 357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.