Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL865468 | 0.95 | HTR1A (0.43) | KDM4EHTR1ALOXL2LMNAMAPT | |
| SCHEMBL866002 | 0.89 | LOXL2 (0.43) | KDM4ELOXL2GPR84LMNAMAPT | |
| SCHEMBL1461108 | 0.88 | GHSR (0.47) | KDM4EHTR1AGPR84LMNAHIF1A | |
| SCHEMBL864772 | 0.84 | KDM4E (0.46) | KDM4EHTR1ALOXL2LMNAMAPT | |
| SCHEMBL27513309 | 0.81 | KDM4E (0.45) | KDM4EHTR1ASKP2GPR84LMNA | |
| SCHEMBL16894418 | 0.78 | CYP2A6 (0.47) | KDM4EHTR1ASKP2GPR84LMNA | |
| SCHEMBL867534 | 0.77 | LOXL2 (0.50) | KDM4EHTR1ALOXL2MAPTCYP1A2 | |
| SCHEMBL1313330 | 0.76 | LOXL2 (0.46) | HTR1ALOXL2GPR84HTR1DHTR1B | |
| SCHEMBL1537772 | 0.75 | SKP2 (0.55) | KDM4ESKP2LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL31593167 | 0.75 | SKP2 (0.55) | KDM4ESKP2LMNASMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606887-A1 | DIINDOLYLMETHANE, PRECURSOR AND DERIVATIVES THEREOF IN PREPARATION OF MEDICAMENTS FOR TREATING LIVER DISEASES | Nanjing University (CN) | 2013-06-26 | — | — | EP | claimed |
| EP-2314294-A2 | 3,3'-diindolylmethane immune activating compositions | The Regents of The University of California (US) | 2011-04-27 | — | — | EP | claimed |
| US-20060100264-A1 | 3,3'-Diindolylmethane immune activating compositions | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-05-11 | — | — | US | claimed |
| EP-1328513-A2 | DIINDOLYLMETHANE AND C-SUBSTITUTED DIINDOLYLMETHANE COMPOSITIONS AND METHODS FOR THE TREATMENT OF MULTIPLE CANCERS | The Texas A & M University System (US) | 2003-07-23 | — | — | EP | claimed |
| EP-0971890-B1 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | TEXAS A & M UNIV SYS (US) | 2002-11-27 | — | — | EP | claimed |
| US-20020115708-A1 | Diindolylmethane and C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers | TEXAS A&M UNIVERSITY SYSTEM, THE | 2002-08-22 | — | — | US | claimed |
| WO-2002028832-A2 | DIINDOLYLMETHANE AND C-SUBSTITUTED DIINDOLYLMETHANE COMPOSITIONS AND METHODS FOR THE TREATMENT OF MULTIPLE CANCERS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 2002-04-11 | — | — | WO | claimed |
| EP-0971890-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2000-01-19 | — | — | EP | claimed |
| US-5948808-A | Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 1999-09-07 | — | — | US | claimed |
| WO-1998050357-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 1998-11-12 | — | — | WO | claimed |
| US-20220280479-A1 | SELF-EMULSIFYING FORMULATIONS OF DIM-RELATED INDOLES | BIORESPONSE, L.L.C. | 2022-09-08 | — | — | US | disclosed |
| US-11337961-B2 | Self-emulsifying formulations of DIM-related indoles | BIORESPONSE, L.L.C. (US) | 2022-05-24 | — | — | US | disclosed |
| US-20210046046-A1 | SELF-EMULSIFYING FORMULATIONS OF DIM-RELATED INDOLES | BIORESPONSE, L.L.C. | 2021-02-18 | — | — | US | disclosed |
| US-10799479-B2 | Self-emulsifying formulations of DIM-related indoles | BIORESPONSE, L.L.C. (US) | 2020-10-13 | — | — | US | disclosed |
| US-10441569-B2 | Self-emulsifying formulations of DIM-related indoles | BIORESPONSE, L.L.C. (US) | 2019-10-15 | — | — | US | disclosed |
| US-20020115708-A1 | Diindolylmethane and C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers | TEXAS A&M UNIVERSITY SYSTEM, THE | 2002-08-22 | — | — | US | disclosed |
| WO-2002028832-A2 | DIINDOLYLMETHANE AND C-SUBSTITUTED DIINDOLYLMETHANE COMPOSITIONS AND METHODS FOR THE TREATMENT OF MULTIPLE CANCERS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 2002-04-11 | — | — | WO | disclosed |
| EP-0971890-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2000-01-19 | — | — | EP | disclosed |
| US-5948808-A | Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 1999-09-07 | — | — | US | disclosed |
| WO-1998050357-A2 | SUBSTITUTED ANALOGS OF INDOLE-3-CARBINOL AND OF DIINDOLYMETHANE AS ANTIESTROGENS | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 1998-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220280479-A1 | SELF-EMULSIFYING FORMULATIONS OF DIM-RELATED INDOLES | IDO1, IDO2, CYP8B1 | KDM4E 1237/4885HTR1A 37/4885SKP2 635/4885 |
| US-20020115708-A1 | Diindolylmethane and C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers | KRAS, VHL, TP53 | KDM4E 530/4885HTR1A 3827/4885SKP2 1150/4885 |
| US-10441569-B2 | Self-emulsifying formulations of DIM-related indoles | IDO1, IDO2, CYP8B1 | KDM4E 1237/4885HTR1A 37/4885SKP2 635/4885 |
| US-20060100264-A1 | 3,3'-Diindolylmethane immune activating compositions | CD69, ICOS, CD14 | KDM4E 3050/4885HTR1A 2254/4885SKP2 3541/4885 |
| US-20210046046-A1 | SELF-EMULSIFYING FORMULATIONS OF DIM-RELATED INDOLES | IDO1, IDO2, CYP8B1 | KDM4E 1307/4885HTR1A 37/4885SKP2 507/4885 |
| US-11337961-B2 | Self-emulsifying formulations of DIM-related indoles | IDO1, IDO2, CYP8B1 | KDM4E 1307/4885HTR1A 37/4885SKP2 507/4885 |
| US-10799479-B2 | Self-emulsifying formulations of DIM-related indoles | IDO1, IDO2, CYP8B1 | KDM4E 1307/4885HTR1A 37/4885SKP2 507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.