Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8646446 | 0.83 | HDAC1 (0.57) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL3530258 | 0.82 | KMT2A (0.64) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL1899410 | 0.81 | NPSR1 (0.57) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL14677951 | 0.81 | NOS2 (0.50) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL2828029 | 0.81 | F10 (0.57) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL13222201 | 0.80 | ALDH1A1 (0.70) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL19634740 | 0.79 | LOXL2 (0.64) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL19634801 | 0.79 | SLC7A5 (0.58) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL4344951 | 0.78 | GSK3B (0.53) | GSK3BPTPN1 | |
| SCHEMBL30988817 | 0.78 | GSK3B (0.53) | GSK3BPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0545376-B1 | Guanidino thiazoles and their use as H2-receptor antagonist | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-09-09 | — | — | EP | disclosed |
| US-5532258-A | ANTIULCER AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-07-02 | — | — | US | disclosed |
| EP-0545376-A1 | Guanidino thiazoles and their use as H2-receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-09 | — | — | EP | disclosed |