Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | TACR3 | P29371 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 5/20 | 0.32 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8647457 | 0.95 | LMNA (0.33) | MAPTPTGS1AKR1C3AKR1C2TACR1 | |
| SCHEMBL8645908 | 0.89 | MAPT (0.35) | MAPTPTGS1AKR1C3AKR1C2TACR1 | |
| SCHEMBL8645900 | 0.86 | MAPT (0.34) | MAPTPTGS1AKR1C3AKR1C2TACR1 | |
| SCHEMBL8647012 | 0.86 | LMNA (0.33) | MAPTPTGS1AKR1C3AKR1C2TACR1 | |
| SCHEMBL8647005 | 0.83 | LMNA (0.34) | MAPTLMNATP53POLBHDAC1 | |
| SCHEMBL8644950 | 0.83 | AMPD2 (0.38) | MAPTTACR1TACR3POLB | |
| SCHEMBL8645861 | 0.82 | MAPT (0.44) | MAPTLMNATP53GAAPOLB | |
| SCHEMBL8644943 | 0.81 | AMPD2 (0.39) | TACR1TACR3POLBHDAC1HDAC6 | |
| SCHEMBL8645856 | 0.81 | MAPT (0.40) | MAPTLMNATP53GAAPOLB | |
| SCHEMBL8647266 | 0.81 | KMT2A (0.37) | TACR1TACR3LMNAGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843972-A | Heterocyclic β-adrenergic agonists | PFIZER INC. (US) | 1998-12-01 | — | — | US | disclosed |
| EP-0801060-A1 | Heterocyclic Beta-3 Adrenergenic Agonists | PFIZER INC. (US) | 1997-10-15 | — | — | EP | disclosed |