Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8647266 | 0.87 | KMT2A (0.37) | LMNAGAAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL8645908 | 0.84 | MAPT (0.35) | MAPTLMNATP53POLB | |
| SCHEMBL8646109 | 0.82 | GAA (0.42) | MAPTLMNAGAATP53TSHR | |
| SCHEMBL8644943 | 0.81 | AMPD2 (0.39) | POLB | |
| SCHEMBL8648264 | 0.81 | MAPT (0.33) | MAPTLMNAGAATP53POLB | |
| SCHEMBL8644950 | 0.80 | AMPD2 (0.38) | MAPTPOLB | |
| SCHEMBL8647457 | 0.80 | LMNA (0.33) | MAPTLMNATP53POLBTSHR | |
| SCHEMBL8645865 | 0.79 | MAPT (0.38) | MAPTTP53ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL8645858 | 0.72 | ALDH1A1 (0.42) | MAPTLMNAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL8646423 | 0.72 | LMNA (0.48) | LMNATP53POLBALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843972-A | Heterocyclic β-adrenergic agonists | PFIZER INC. (US) | 1998-12-01 | — | — | US | disclosed |
| EP-0801060-A1 | Heterocyclic Beta-3 Adrenergenic Agonists | PFIZER INC. (US) | 1997-10-15 | — | — | EP | disclosed |