Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.60 |
| ▸ | RGS12 | O14924 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.60 |
| ▸ | PTGES | O14684 | 2/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8360558 | 0.88 | ALDH1A1 (0.50) | ALDH1A1TSHRLMNACYP1A2CYP2C9 | |
| SCHEMBL8645800 | 0.85 | CNR2 (0.55) | ALDH1A1TSHRLMNACYP1A2CYP2C9 | |
| SCHEMBL2006287 | 0.82 | PLA2G2A (0.66) | ALDH1A1TSHRLMNACYP1A2CYP2C9 | |
| SCHEMBL27475357 | 0.80 | ALDH1A1 (0.51) | ALDH1A1TSHRLMNACYP1A2CYP2C9 | |
| SCHEMBL9545755 | 0.79 | PLA2G2A (0.71) | ALDH1A1TSHRLMNACYP1A2CYP2C9 | |
| SCHEMBL6025562 | 0.78 | MAPT (0.73) | ALDH1A1TSHRLMNACYP1A2CYP2C9 | |
| SCHEMBL2007815 | 0.76 | LMNA (0.58) | ALDH1A1TSHRLMNACYP1A2CYP2C9 | |
| SCHEMBL1322507 | 0.75 | LMNA (1.00) | ALDH1A1TSHRLMNACYP1A2CYP2C9 | |
| SCHEMBL8360559 | 0.75 | KDM4E (0.50) | ALDH1A1TSHRLMNACYP1A2CYP2C9 | |
| SCHEMBL3001920 | 0.75 | PLA2G2A (0.67) | ALDH1A1TSHRLMNACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0746544-B1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMA INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0746544-A1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMACEUTICALS INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995022524-A1 | NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS | MERRELL PHARMACEUTICALS INC. (US) | 1995-08-24 | — | — | WO | disclosed |