Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | MITF | O75030 | 2/20 | 0.44 |
| ▸ | CCR6 | P51684 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | KDM4B | O94953 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557228 | 0.78 | ALOX5 (0.46) | MAPTALOX5L3MBTL1MITFCCR6 | |
| SCHEMBL8557217 | 0.78 | ALOX5 (0.60) | MAPTALOX5ADORA3 | |
| SCHEMBL7598120 | 0.74 | ALDH1A1 (0.45) | MAPTALOX5L3MBTL1MITFCCR6 | |
| SCHEMBL8649479 | 0.74 | CYSLTR2 (0.53) | MAPTL3MBTL1ALDH1A1PKMPPP1CA | |
| SCHEMBL8557961 | 0.72 | MAPT (0.42) | MAPTALOX5L3MBTL1MITFCCR6 | |
| SCHEMBL8646511 | 0.72 | CYSLTR2 (0.63) | ALOX5 | |
| SCHEMBL6000209 | 0.71 | PTPN2 (0.58) | MAPTALOX5L3MBTL1PKMPPARD | |
| SCHEMBL6001006 | 0.71 | PTPN2 (0.55) | MAPTALOX5L3MBTL1KDM4EPPARD | |
| SCHEMBL6000619 | 0.71 | PTPN2 (0.55) | MAPTALOX5L3MBTL1PPARDPPARA | |
| SCHEMBL6619798 | 0.71 | CYP1A2 (0.39) | ALDH1A1KDM4EPPARDPPARAKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862557-A1 | SYMMETRICAL bis-HETEROARYLMETHOXYPHENYLALKYL CARBOXYLATES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | Abbott Laboratories (US) | 1998-09-09 | — | — | EP | disclosed |
| WO-1997012867-A1 | SYMMETRICAL bis-HETEROARYLMETHOXYPHENYLALKYL CARBOXYLATES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1997-04-10 | — | — | WO | disclosed |