SCHEMBL864952

SCHEMBL864952

Nc1ccccc1Sc1cc(C(F)(F)F)cc([N+](=O)[O-])c1Sc1ccccc1N

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.79
LMNA P02545 5/20 0.79
PDE7A Q13946 7/20 0.67
SMN1; SMN2 Q16637 2/20 0.67
HTT P42858 1/20 0.58
POLB P06746 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
ALDH1A1 P00352 4/20 0.51
KDM4E B2RXH2 1/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
HPGD P15428 2/20 0.46
GAA P10253 1/20 0.46
PTPN5 P54829 1/20 0.45
CYP3A4 P08684 1/20 0.44
ALOX15 P16050 1/20 0.44
TSHR P16473 1/20 0.44
HIF1A Q16665 1/20 0.44
TXNRD1 Q16881 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30605781 1.00 MAPT (0.79) MAPTLMNAPDE7ASMN1; SMN2HTT
SCHEMBL8095611 0.81 PDE7A (1.00) MAPTLMNAPDE7ASMN1; SMN2HTT
SCHEMBL18839947 0.79 MAPT (0.56) MAPTLMNAPDE7ASMN1; SMN2HTT
SCHEMBL1455439 0.75 PDE7A (0.74) MAPTLMNAPDE7ASMN1; SMN2POLB
SCHEMBL3357437 0.73 PDE7A (0.58) MAPTLMNAPDE7ASMN1; SMN2HTT
SCHEMBL19745705 0.72 PDE7A (0.70) MAPTLMNAPDE7ASMN1; SMN2POLB
SCHEMBL2964985 0.72 PDE7A (0.70) MAPTLMNAPDE7ASMN1; SMN2POLB
SCHEMBL7607819 0.72 PDE7A (1.00) MAPTLMNAPDE7ASMN1; SMN2POLB
SCHEMBL31272173 0.71 PDE7A (0.78) MAPTLMNAPDE7ASMN1; SMN2ALDH1A1
SCHEMBL875772 0.71 PDE7A (0.78) MAPTLMNAPDE7ASMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250180952-A1 PHOTOALIGNING MATERIALS Rolic Technologies AG (CH) 2025-06-05 US disclosed
US-11634544-B2 Photoaligning materials Rolic Technologies AG (CH) 2023-04-25 US disclosed
US-20210340330-A1 PHOTOALIGNING MATERIALS Rolic Technologies AG (CH) 2021-11-04 US disclosed
US-20200223984-A1 PHOTOALIGNING MATERIALS Rolic Technologies AG (CH) 2020-07-16 US disclosed
US-10696795-B2 Photoaligning materials Rolic Technologies AG (CH) 2020-06-30 US disclosed
EP-3374467-B1 COMPOSITIONS OF PHOTO-ALIGNABLE MATERIALS ROLIC TECH AG (CH) 2020-04-15 EP disclosed
US-10558089-B2 Photoalignment composition ROLIC AG (CH) 2020-02-11 US disclosed
EP-2222815-B1 PHOTOALIGNMENT COMPOSITION ROLIC TECH AG (CH) 2019-05-29 EP disclosed
US-10208031-B2 Photocrosslinkable materials comprising alicyclic group ROLIC AG (CH) 2019-02-19 US disclosed
US-20180319939-A1 PHOTOALIGNING MATERIALS Rolic Technologies AG (CH) 2018-11-08 US disclosed
EP-2305632-A1 Photocrosslinkable materials Rolic AG (CH) 2011-04-06 EP disclosed
US-20100266814-A1 PHOTOALIGNMENT COMPOSITION ROLIC AG (CH) 2010-10-21 US disclosed
EP-2222815-A1 PHOTOALIGNMENT COMPOSITION Rolic Ltd. (CH) 2010-09-01 EP disclosed
US-20100048849-A1 PHOTOCROSSLINKABLE MATERIALS COMPRISING ALICYCLIC GROUP ROLIC AG (CH) 2010-02-25 US disclosed
EP-2152660-A2 PHOTOCROSSLINKABLE MATERIALS COMPRISING ALICYCLIC GROUP Rolic AG (CH) 2010-02-17 EP disclosed
WO-2009080271-A1 PHOTOALIGNMENT COMPOSITION ROLIC LTD. (CH) 2009-07-02 WO disclosed
WO-2008145225-A2 PHOTOCROSSLINKABLE MATERIALS COMPRISING ALICYCLIC GROUP ROLIC AG (CH) 2008-12-04 WO disclosed
US-20080293888-A1 Photocrosslinkable Materials ROLIC AG (CH) 2008-11-27 US disclosed
EP-1966119-A1 PHOTOCROSSLINKABLE MATERIALS Rolic AG (CH) 2008-09-10 EP disclosed
WO-2007071091-A1 PHOTOCROSSLINKABLE MATERIALS ROLIC AG (CH) 2007-06-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10208031-B2 Photocrosslinkable materials comprising alicyclic group DDC, ALAD, DYNC1LI1 MAPT 1424/4885LMNA 590/4885PDE7A 3970/4885
US-20100048849-A1 PHOTOCROSSLINKABLE MATERIALS COMPRISING ALICYCLIC GROUP DDC, ALAD, DYNC1LI1 MAPT 1424/4885LMNA 590/4885PDE7A 3970/4885
US-20080293888-A1 Photocrosslinkable Materials DDC, PARG, ALAD MAPT 295/4885LMNA 2057/4885PDE7A 3997/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.