Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.64 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.64 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.64 |
| ▸ | HTR6 | P50406 | 2/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.55 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.55 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.55 |
| ▸ | AHR | P35869 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | CNR2 | P34972 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8245339 | 0.87 | HDAC1 (0.50) | CHRNB2CHRNA7CHRNA4HTR6CHRM1 | |
| SCHEMBL18509023 | 0.84 | MAPT (0.56) | HDAC1HDAC2HDAC8HDAC6HDAC9 | |
| SCHEMBL7390217 | 0.84 | HDAC1 (0.62) | CHRNB2CHRNA7CHRNA4HTR6HDAC1 | |
| SCHEMBL20483547 | 0.84 | CHRNB2 (0.62) | CHRNB2CHRNA7CHRNA4HTR6CHRM1 | |
| SCHEMBL16494825 | 0.82 | HTR6 (0.64) | HTR6CHRM1KMT2ALMNAALDH1A1 | |
| SCHEMBL12225809 | 0.81 | POLB (0.63) | HDAC1HDAC2HDAC8HDAC6HDAC9 | |
| SCHEMBL797463 | 0.80 | ALDH1A1 (0.69) | CHRNB2CHRNA7CHRNA4HTR6CHRM1 | |
| SCHEMBL8757568 | 0.79 | HTR6 (0.73) | CHRNB2CHRNA7CHRNA4HTR6CHRM1 | |
| SCHEMBL12472337 | 0.79 | HDAC6 (0.73) | CHRM1HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL8081491 | 0.79 | HDAC1 (0.54) | HTR6HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998005327-A1 | SUBSTITUTED AROMATIC COMPOUNDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-02-12 | — | — | WO | disclosed |