Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.43 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18509023 | 0.89 | MAPT (0.56) | HDAC1HDAC2HDAC8HDAC6HDAC9 | |
| SCHEMBL8650552 | 0.87 | CHRNB2 (0.64) | HDAC1HDAC2HDAC8HDAC6HDAC9 | |
| SCHEMBL8252334 | 0.81 | HTR2C (0.48) | MEN1KMT2AHTR6MAPT | |
| SCHEMBL28239560 | 0.81 | POLB (0.60) | POLBSMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL7390217 | 0.79 | HDAC1 (0.62) | HDAC1HDAC2HDAC8HDAC6HDAC9 | |
| SCHEMBL16494825 | 0.78 | HTR6 (0.64) | KMT2AHTR6CHRM1PLA2G2A | |
| SCHEMBL8081491 | 0.78 | HDAC1 (0.54) | HDAC1HDAC2HDAC8HDAC6HDAC9 | |
| SCHEMBL12225809 | 0.74 | POLB (0.63) | HDAC1HDAC2HDAC8HDAC6HDAC9 | |
| SCHEMBL18508845 | 0.73 | ALDH1A1 (0.65) | HDAC1HDAC2HDAC8HDAC6HDAC9 | |
| SCHEMBL14363281 | 0.73 | HDAC1 (0.56) | HDAC1HDAC2HDAC8HDAC6HDAC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137566-A1 | Substituted Piperdines as Renin Inhibitors | EHARA TAKERU | 2009-05-28 | — | — | US | disclosed |
| WO-2006125621-A1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137566-A1 | Substituted Piperdines as Renin Inhibitors | REN, ACE, AGTR1 | HDAC1 2172/4885HDAC2 2203/4885HDAC8 3723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.