Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8644322 | 0.91 | MAPT (0.42) | NPC1RAB9AGAAKMT2AMAPT | |
| SCHEMBL8648674 | 0.90 | KMT2A (0.47) | NPC1RAB9AGAAKMT2AMAPT | |
| SCHEMBL8646761 | 0.88 | CYP3A4 (0.45) | NPC1RAB9AKMT2AMAPTMEN1 | |
| SCHEMBL8650931 | 0.87 | ATM (0.37) | NPC1RAB9AGAAMAPTCYP1A1 | |
| SCHEMBL8647072 | 0.86 | ALDH1A1 (0.52) | RAB9AGAAKMT2AMEN1ALDH1A1 | |
| SCHEMBL8648668 | 0.86 | ALDH1A1 (0.35) | NPC1RAB9AKMT2AMAPTMEN1 | |
| SCHEMBL8646248 | 0.86 | MAPT (0.43) | NPC1RAB9AKMT2AMAPTMEN1 | |
| SCHEMBL8647153 | 0.85 | CYP1A1 (0.47) | NPC1RAB9AGAAKMT2AMAPT | |
| SCHEMBL8650927 | 0.85 | NPC1 (0.45) | NPC1RAB9AGAAKMT2AMAPT | |
| SCHEMBL8645267 | 0.81 | CYP1A1 (0.47) | NPC1RAB9AGAAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861831-A1 | HETEROARYL-SUBSTITUTED ACRYLOYLGUANIDINE DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-09-02 | — | — | EP | disclosed |