Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | DAO | P14920 | 1/20 | 0.64 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.64 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.56 |
| ▸ | CES1 | P23141 | 3/20 | 0.54 |
| ▸ | CES2 | O00748 | 2/20 | 0.54 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL10952729 | 0.88 | TSHR (0.74) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL30599484 | 0.88 | TSHR (0.74) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL11767340 | 0.88 | TSHR (0.74) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL3311083 | 0.88 | TSHR (0.74) | TSHRDAONAPRTNR4A2CES1 | |
| Benzoic Acid SCHEMBL15485652 | 0.86 | NR4A2 (0.74) | TSHRDAONAPRTNR4A2CES1 | |
| Benzoic Acid SCHEMBL11455168 | 0.86 | TSHR (0.70) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL1573399 | 0.86 | TSHR (0.70) | TSHRDAONAPRTNR4A2CES1 | |
| Benzoic Acid SCHEMBL27206572 | 0.86 | TSHR (0.70) | TSHRDAONAPRTNR4A2CES1 | |
| Benzoic Acid SCHEMBL31376992 | 0.85 | TSHR (0.78) | TSHRDAONAPRTCES1CES2 | |
| Adipic Acid SCHEMBL7202698 | 0.84 | HDAC3 (0.69) | TSHRDAONAPRTNR4A2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710012-A | DETECTION OF CHOLESTEROL BY RELEASE OF HYDROGEN PEROXIDE | ACTIMED LABORATORIES, INC. (US) | 1998-01-20 | — | — | US | claimed |
| US-20250152533-A1 | Novel Beta-Alanine Compositions and Methods of Use Thereof | LEGACY CORPORATE LENDING, LLC, AS ADMINISTRATIVE AGENT | 2025-05-15 | — | — | US | disclosed |
| US-5710012-A | DETECTION OF CHOLESTEROL BY RELEASE OF HYDROGEN PEROXIDE | ACTIMED LABORATORIES, INC. (US) | 1998-01-20 | — | — | US | disclosed |
| US-5518891-A | SUBSTITUTED ANILINES, HYDRAZONES OR 4-AMINOANTIPYRINES | ACTIMED LABORATORIES, INC. (US) | 1996-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250152533-A1 | Novel Beta-Alanine Compositions and Methods of Use Thereof | GYS1, PYGM, AADAT | TSHR 4665/4885DAO 98/4885NAPRT 2430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.