Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | ICMT | O60725 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | CCND1 | P24385 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8873453 | 0.91 | OPRK1 (0.48) | OPRK1DRD2DRD3KMT2AMEN1 | |
| SCHEMBL8956847 | 0.87 | TACR1 (0.58) | OPRK1DRD2DRD3KMT2AMEN1 | |
| SCHEMBL8956681 | 0.87 | TACR1 (0.58) | OPRK1DRD2DRD3KMT2AMEN1 | |
| SCHEMBL8875525 | 0.87 | FNTA (0.51) | KMT2AMEN1LMNATACR1SMN1; SMN2 | |
| SCHEMBL8873635 | 0.84 | DRD2 (0.49) | OPRK1DRD2DRD3KMT2AMEN1 | |
| SCHEMBL8876006 | 0.80 | DRD2 (0.48) | OPRK1DRD2DRD3KMT2AMEN1 | |
| SCHEMBL8956827 | 0.80 | TACR1 (0.55) | OPRK1DRD2DRD3KMT2AMEN1 | |
| SCHEMBL9243104 | 0.80 | TACR1 (0.55) | OPRK1DRD2DRD3KMT2AMEN1 | |
| SCHEMBL8874906 | 0.80 | DRD2 (0.49) | OPRK1DRD2DRD3KMT2AMEN1 | |
| SCHEMBL9245521 | 0.79 | TACR1 (0.54) | OPRK1DRD2DRD3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711280-B1 | PERHYDROISOINDOLE DERIVATIVES AS P SUBSTANCE ANTAGONISTS | RHONE POULENC RORER SA (FR) | 1998-09-23 | — | — | EP | claimed |
| US-5624950-A | USEFUL IN TREATMENT OF ANALGESIA, INFLAMMATION, ASTHMA, ALLERGIES, CENTRAL NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS, IMMUNE SYSTEM DISORDERS, ANTISPASMODIC AGENTS, ANTIEMETIC AGENTS | RHONE-POULENC RORER S.A. (FR) | 1997-04-29 | — | — | US | claimed |
| US-5624950-A | USEFUL IN TREATMENT OF ANALGESIA, INFLAMMATION, ASTHMA, ALLERGIES, CENTRAL NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS, IMMUNE SYSTEM DISORDERS, ANTISPASMODIC AGENTS, ANTIEMETIC AGENTS | RHONE-POULENC RORER S.A. (FR) | 1997-04-29 | — | — | US | disclosed |