Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.57 |
| ▸ | BHMT | Q93088 | 3/20 | 0.42 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 5/20 | 0.40 |
| ▸ | NOS3 | P29474 | 4/20 | 0.40 |
| ▸ | NOS2 | P35228 | 5/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | ARG2 | P78540 | 4/20 | 0.38 |
| ▸ | ARG1 | P05089 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL3442577 | 0.96 | GSR (0.62) | GSRBHMTBHMT2NOS1NOS3 | |
| Lysine SCHEMBL12469851 | 0.94 | GSR (0.65) | GSRBHMTBHMT2NOS1NOS3 | |
| Lysine SCHEMBL1345091 | 0.89 | GSR (0.71) | GSRBHMTBHMT2NOS1NOS3 | |
| Methionine SCHEMBL3883236 | 0.89 | BHMT (0.50) | GSRBHMTBHMT2NOS1NOS3 | |
| Lysine SCHEMBL10491088 | 0.89 | GSR (0.71) | GSRBHMTBHMT2NOS1NOS3 | |
| Lysine SCHEMBL938951 | 0.89 | GSR (0.71) | GSRBHMTBHMT2NOS1NOS3 | |
| Lysine SCHEMBL7530112 | 0.89 | GSR (0.71) | GSRNOS1NOS3NOS2CYP2C19 | |
| Lysine SCHEMBL8720001 | 0.89 | GSR (0.71) | GSRBHMTBHMT2NOS1NOS3 | |
| Lysine SCHEMBL1345092 | 0.89 | GSR (0.71) | GSRBHMTBHMT2NOS1NOS3 | |
| Methionine SCHEMBL3239125 | 0.89 | BHMT (0.50) | GSRBHMTBHMT2NOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0057350-B1 | Recombinant DNA means and method | COLLABORATIVE RES INC (US) | 1998-10-21 | — | — | EP | disclosed |
| US-5525484-A | GENETICALLY ENGINEERED BACTERIA OR YEAST CELLS CONTAINING GENETIC MATERIAL FROM RECOMBINANT DNA WHICH CODES FOR BOVINE RENNIN | GENOME THERAPEUTICS CORP. (US) | 1996-06-11 | — | — | US | disclosed |
| US-5496711-A | GENETIC ENGINEERING WITH DNA USING FUNGI, YEASTS AND BACTERIA | GENOME THERAPEUTICS CORP. (US) | 1996-03-05 | — | — | US | disclosed |
| EP-0057350-A2 | Recombinant DNA means and method | Collaborative Research Inc. (US) | 1982-08-11 | — | — | EP | disclosed |