SCHEMBL8655762

SCHEMBL8655762

Sc1nnnn1-c1ccc(-n2nnnc2S)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 11/20 0.41
LMNA P02545 6/20 0.41
MAPT P10636 5/20 0.41
HPGD P15428 4/20 0.41
HTT P42858 4/20 0.41
NPSR1 Q6W5P4 4/20 0.41
L3MBTL1 Q9Y468 3/20 0.41
HSP90AA1 P07900 2/20 0.41
CACNA1B Q00975 2/20 0.41
APBA1 Q02410 2/20 0.41
TP53 P04637 1/20 0.41
NLRP1 Q9C000 1/20 0.41
HSD17B10 Q99714 1/20 0.40
CCR6 P51684 1/20 0.39
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
TSHR P16473 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
PKM P14618 1/20 0.35
NLRP3 Q96P20 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8048128 0.89 ALDH1A1 (0.49) ALDH1A1LMNAMAPTHTTMEN1
SCHEMBL14119061 0.89 ALDH1A1 (0.46) ALDH1A1LMNAMAPTHPGDHTT
SCHEMBL5685523 0.89 MAPT (0.56) ALDH1A1LMNAMAPTHPGDHTT
SCHEMBL8048129 0.89 ALDH1A1 (0.38) ALDH1A1LMNAMAPTHPGDHTT
SCHEMBL55213 0.89 ALDH1A1 (0.53) ALDH1A1LMNAMAPTHPGDHTT
SCHEMBL2415227 0.87 ALDH1A1 (0.52) ALDH1A1LMNAMAPTHPGDHTT
SCHEMBL8088255 0.87 ALDH1A1 (0.52) ALDH1A1LMNAMAPTHPGDHTT
SCHEMBL3298388 0.84 ALDH1A1 (0.55) ALDH1A1LMNAMAPTHPGDHTT
SCHEMBL1250352 0.84 PTGS2 (0.50) ALDH1A1LMNAMAPTHPGDHTT
SCHEMBL10022440 0.84 NOTUM (0.46) ALDH1A1LMNAMAPTHPGDHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116655609-B Preparation method of pitavastatin key intermediate 江苏阿尔法药业股份有限公司 2024-07-30 CN disclosed
US-11814355-B2 Method for synthesizing pitavastatin t-butyl ester ANHUI QINGYUN PHARMACEUTICAL AND CHEMICAL CO., LTD. (CN) 2023-11-14 US disclosed
US-11814355-B2 Method for synthesizing pitavastatin t-butyl ester ANHUI QINGYUN PHARMACEUTICAL AND CHEMICAL CO., LTD. (CN) 2023-11-14 US disclosed
CN-116655609-A Preparation method of pitavastatin key intermediate 江苏阿尔法药业股份有限公司 2023-08-29 CN disclosed
CN-111875538-B Synthetic method of pitavastatin tert-butyl ester 安徽省庆云医药股份有限公司 2022-05-17 CN disclosed
CN-109574999-B Preparation method of pitavastatin calcium intermediate 安徽省庆云医药股份有限公司 2022-03-08 CN disclosed
CN-109574998-B Synthetic method of pitavastatin calcium intermediate 安徽省庆云医药股份有限公司 2022-03-08 CN disclosed
CN-111875538-A Synthetic method of pitavastatin tert-butyl ester 安徽省庆云医药股份有限公司 2020-11-03 CN disclosed
EP-1810081-B1 PHOTOPOLYMERIZABLE COMPOSITION AGFA NV (BE) 2020-01-08 EP disclosed
US-20150287953-A1 TRANSPARENT ELECTRODE, ELECTRONIC DEVICE, AND ORGANIC ELECTROLUMINESCENT ELEMENT Konica Minolta, Inc. (JP) 2015-10-08 US disclosed
US-5085971-A Redox system capable of releasing development inhibitor by oxidation and a hydrazine compound FUJI PHOTO FILM CO., LTD. (JP) 1992-02-04 US disclosed
EP-0442323-A2 Silver halide color reversal photographic material capable of providing interimage effect FUJI PHOTO FILM CO., LTD. (JP) 1991-08-21 EP disclosed
EP-0436027-A1 METHOD OF TREATING SILVER HALIDE PHOTOGRAPHIC MATERIAL FUJI PHOTO FILM CO., LTD. (JP) 1991-07-10 EP disclosed
US-5006444-A Silver halide photographic material FUJI PHOTO FILM CO., LTD. (JP) 1991-04-09 US disclosed
EP-0420005-A1 high contrast silver halide photographic material FUJI PHOTO FILM CO., LTD. (JP) 1991-04-03 EP disclosed
EP-0398285-A2 Silver halide photographic materials FUJI PHOTO FILM CO., LTD. (JP) 1990-11-22 EP disclosed
EP-0395069-A2 Silver halide photographic materials FUJI PHOTO FILM CO., LTD. (JP) 1990-10-31 EP disclosed
EP-0393720-A2 Silver halide photographic materials FUJI PHOTO FILM CO., LTD. (JP) 1990-10-24 EP disclosed
EP-0335319-A2 Silver halide photographic material FUJI PHOTO FILM CO., LTD. (JP) 1989-10-04 EP disclosed
US-4737442-A INCLUDING A SENSITIZER AND A BLOCKED DEVELOPMENT RESTRAINER; FREE OF BLACK SPOTS FUJI PHOTO FILM CO., LTD. (JP) 1988-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11814355-B2 Method for synthesizing pitavastatin t-butyl ester SSTR4, DPP4, VIP ALDH1A1 729/4885LMNA 2649/4885MAPT 2889/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.