SCHEMBL1250352

SCHEMBL1250352

CN(C)c1ccc(-n2nnnc2S)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 3/20 0.50
MAPT P10636 7/20 0.49
MEN1 O00255 5/20 0.49
KMT2A Q03164 5/20 0.49
KDM4E B2RXH2 4/20 0.49
NPSR1 Q6W5P4 3/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
ALDH1A1 P00352 8/20 0.49
SMN1; SMN2 Q16637 3/20 0.49
LMNA P02545 3/20 0.49
RAB9A P51151 2/20 0.49
NPC1 O15118 1/20 0.49
GFER P55789 1/20 0.49
POLB P06746 2/20 0.42
L3MBTL1 Q9Y468 2/20 0.40
GAA P10253 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8655762 0.84 ALDH1A1 (0.41) MAPTMEN1KMT2ANPSR1ALDH1A1
SCHEMBL6261662 0.83 ALDH1A1 (0.53) PTGS2MAPTMEN1KMT2AKDM4E
SCHEMBL10959889 0.81 MAPT (0.38) PTGS2MAPTMEN1KMT2AKDM4E
SCHEMBL10336884 0.80 PTGS2 (0.40) PTGS2MAPTMEN1KMT2AKDM4E
SCHEMBL3300508 0.80 PTGS2 (0.43) PTGS2MAPTMEN1KMT2AKDM4E
SCHEMBL6264097 0.79 ALDH1A1 (0.56) PTGS2MAPTMEN1KMT2AKDM4E
SCHEMBL8048128 0.76 ALDH1A1 (0.49) PTGS2MAPTMEN1KMT2AKDM4E
SCHEMBL8048129 0.76 ALDH1A1 (0.38) PTGS2MAPTMEN1KMT2AKDM4E
SCHEMBL5685523 0.76 MAPT (0.56) PTGS2MAPTNPSR1CYP1A2CYP2C19
SCHEMBL594488 0.76 ALDH1A1 (0.47) MAPTMEN1KMT2AKDM4ENPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1914559-B Silver halide color photographic light-sensitive material and color image forming method FUJI PHOTO FILM CO LTD 2011-09-21 CN disclosed
US-7879893-B2 Zinc binding ligand; sustained release of insulin NOVO NORDISK A/S (DK) 2011-02-01 US disclosed
US-7732124-B2 Silver halide color photographic light-sensitive material and color image-forming method FUJIFILM CORPORATION (JP) 2010-06-08 US disclosed
US-7611829-B2 Silver halide color photographic light-sensitive material and color image-forming method FUJIFILM CORPORATION (JP) 2009-11-03 US disclosed
US-20090130613-A1 Silver Halide color photographic light-sensitive material and color image-forming method DEGUCHI YASUAKI 2009-05-21 US disclosed
US-20090123563-A1 Pharmaceutical Preparations Comprising Insulin, Zinc Ions and Zinc-Binding Ligand NOVO NORDISK A/S (DK) 2009-05-14 US disclosed
EP-1914594-A2 Silver halide color photographic light-sensitive material and color image-forming method FUJIFILM Corporation (JP) 2008-04-23 EP disclosed
EP-1585541-B1 PHARMACEUTICAL COMPOSITIONS COMPRISING INSULIN AND LEGENDS OF INSULIN HEXAMER NOVO NORDISK AS (DK) 2007-11-14 EP disclosed
US-20070154853-A1 Silver halide color photographic light-sensitive material and color image-forming method FUJI PHOTO FILM CO., LTD. (JP) 2007-07-05 US disclosed
EP-1709483-A4 SILVER HALIDE COLOR PHOTOGRAPHIC LIGHT-SENSITIVE MATERIAL AND COLOR IMAGE-FORMING METHOD FUJIFILM CORP (JP) 2007-06-27 EP disclosed
EP-0442323-A2 Silver halide color reversal photographic material capable of providing interimage effect FUJI PHOTO FILM CO., LTD. (JP) 1991-08-21 EP disclosed
EP-0436027-A1 METHOD OF TREATING SILVER HALIDE PHOTOGRAPHIC MATERIAL FUJI PHOTO FILM CO., LTD. (JP) 1991-07-10 EP disclosed
US-5006444-A Silver halide photographic material FUJI PHOTO FILM CO., LTD. (JP) 1991-04-09 US disclosed
EP-0420005-A1 high contrast silver halide photographic material FUJI PHOTO FILM CO., LTD. (JP) 1991-04-03 EP disclosed
EP-0398285-A2 Silver halide photographic materials FUJI PHOTO FILM CO., LTD. (JP) 1990-11-22 EP disclosed
EP-0395069-A2 Silver halide photographic materials FUJI PHOTO FILM CO., LTD. (JP) 1990-10-31 EP disclosed
EP-0393720-A2 Silver halide photographic materials FUJI PHOTO FILM CO., LTD. (JP) 1990-10-24 EP disclosed
EP-0335319-A2 Silver halide photographic material FUJI PHOTO FILM CO., LTD. (JP) 1989-10-04 EP disclosed
US-4737442-A INCLUDING A SENSITIZER AND A BLOCKED DEVELOPMENT RESTRAINER; FREE OF BLACK SPOTS FUJI PHOTO FILM CO., LTD. (JP) 1988-04-12 US disclosed
US-4110338-A Product and preparation of 1H-tetrazole-5-thiol derivatives FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1978-08-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090123563-A1 Pharmaceutical Preparations Comprising Insulin, Zinc Ions and Zinc-Binding Ligand IAPP, IRS1, HBB PTGS2 4802/4885MAPT 1785/4885MEN1 912/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.