Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TXNRD1 | Q16881 | 13/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | GSR | P00390 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3219042 | 0.86 | TXNRD1 (0.52) | TXNRD1GSRS1PR4MAPTS1PR1 | |
| SCHEMBL9379235 | 0.78 | ALDH1A1 (0.46) | ALDH1A1HPGDGAACTSBMAPT | |
| SCHEMBL8654025 | 0.77 | MAPK8 (0.32) | ALDH1A1MAPT | |
| SCHEMBL2258349 | 0.76 | PIN1 (0.46) | ALDH1A1HPGDTXNRD1GAAL3MBTL1 | |
| SCHEMBL8657532 | 0.75 | ALDH1A1 (0.46) | ALDH1A1HPGDTXNRD1GAAL3MBTL1 | |
| SCHEMBL9376848 | 0.74 | TXNRD1 (0.46) | ALDH1A1HPGDTXNRD1GAAL3MBTL1 | |
| SCHEMBL27257741 | 0.74 | ALDH1A1 (0.43) | ALDH1A1HPGDTXNRD1GAAL3MBTL1 | |
| SCHEMBL17372594 | 0.74 | TXNRD1 (0.48) | ALDH1A1TXNRD1CTSBGSRS1PR4 | |
| SCHEMBL29210876 | 0.74 | TXNRD1 (0.48) | ALDH1A1TXNRD1CTSBGSRS1PR4 | |
| SCHEMBL14334130 | 0.74 | L3MBTL1 (0.41) | ALDH1A1TXNRD1L3MBTL1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811432-A | Azaoxindole derivatives | PFIZER INC (US) | 1998-09-22 | — | — | US | disclosed |
| CN-1031053-C | Azaoxindole derivatives | PFIZER (US) | 1996-02-21 | — | — | CN | disclosed |
| CN-1025998-C | 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines | PFIZER (US) | 1994-09-28 | — | — | CN | disclosed |
| EP-0379314-B1 | 3-(1,2,5,6-Tetrahydropyridyl)-pyrrolopyridines | PFIZER (US) | 1994-03-23 | — | — | EP | disclosed |
| US-5169947-A | 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines | PFIZER INC. (US) | 1992-12-08 | — | — | US | disclosed |
| US-5051412-A | Pharmaceutically active 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines | PFIZER INC. (US) | 1991-09-24 | — | — | US | disclosed |
| CN-1053065-A | AZAOXINDOLE DERIVATIVES | PFIZER (US) | 1991-07-17 | — | — | CN | disclosed |
| WO-1991009598-A1 | AZAOXINDOLE DERIVATIVES | PFIZER INC. (US) | 1991-07-11 | — | — | WO | disclosed |
| EP-0436333-A2 | Azaoxindole derivatives | PFIZER INC. (US) | 1991-07-10 | — | — | EP | disclosed |
| CN-1044465-A | 3-(1,2,5, the 6-tetrahydro pyridyl)-pyrrolopyridine | PFIZER (US) | 1990-08-08 | — | — | CN | disclosed |
| WO-1990007926-A1 | 3-(1,2,5,6-TETRAHYDROPYRIDYL)-PYRROLOPYRIDINES | PFIZER INC. (US) | 1990-07-26 | — | — | WO | disclosed |
| EP-0379314-A1 | 3-(1,2,5,6-Tetrahydropyridyl)-pyrrolopyridines | PFIZER INC. (US) | 1990-07-25 | — | — | EP | disclosed |