Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 known ✓ | P34969 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | SLC13A5 | Q86YT5 | 8/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.36 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL8657218 | 0.85 | KDM4E (0.70) | LMNAKDM4ESLC13A5L3MBTL1CYP1A2 | |
| Citric Acid SCHEMBL4902056 | 0.68 | KDM4E (0.49) | LMNAKDM4ESLC13A5L3MBTL1CYP1A2 | |
| Citric Acid SCHEMBL28177656 | 0.66 | KDM4E (0.47) | LMNAKDM4ESLC13A5GLAL3MBTL1 | |
| Citric Acid SCHEMBL5185028 | 0.66 | KDM4E (0.48) | LMNAKDM4ESLC13A5CYP1A2CYP2D6 | |
| Phenyltoloxamine SCHEMBL158443 | 0.65 | KDM4E (1.00) | LMNAKDM4EL3MBTL1CYP1A2CYP2D6 | |
| SCHEMBL1628791 | 0.63 | L3MBTL1 (0.62) | KDM4EGLAL3MBTL1HTR7 | |
| SCHEMBL20513873 | 0.63 | SLC1A5 (0.46) | LMNAKDM4EHIF1A | |
| SCHEMBL7755873 | 0.63 | MAOA (0.40) | L3MBTL1P2RX7 | |
| SCHEMBL5254664 | 0.62 | L3MBTL1 (0.64) | THRBGLAL3MBTL1HTR7CYP1A2 | |
| Citric Acid SCHEMBL3454616 | 0.62 | ALDH1A1 (0.79) | LMNAKDM4ESLC13A5CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849931-A | Process for separating carbinols | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 1998-12-15 | — | — | US | disclosed |