Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | HBB | P68871 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8653998 | 0.82 | CHRNB2 (0.36) | MAPK1 | |
| SCHEMBL8653972 | 0.79 | CHRNB2 (0.36) | MAPTLMNACYP2C9KMT2AKDM4E | |
| SCHEMBL8657477 | 0.79 | TDP1 (0.37) | HTTMAPTALOX15LMNAMAPK1 | |
| SCHEMBL30292810 | 0.71 | MAPT (0.52) | HTTMAPTALOX15HBBMEN1 | |
| SCHEMBL16597881 | 0.70 | MAPT (0.55) | HTTMAPTALOX15HBBEP300 | |
| SCHEMBL8654034 | 0.69 | EP300 (0.40) | HTTMAPTALOX15HBBEP300 | |
| SCHEMBL15409306 | 0.65 | MAPT (0.41) | HTTMAPTALOX15HBBEP300 | |
| SCHEMBL28858421 | 0.65 | MAPT (0.41) | HTTMAPTALOX15HBBEP300 | |
| SCHEMBL8654023 | 0.63 | ALDH1A1 (0.35) | HTTMAPTLMNACYP2C9CYP2C19 | |
| SCHEMBL9109997 | 0.63 | NOS1 (0.38) | HTTMAPTLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811432-A | Azaoxindole derivatives | PFIZER INC (US) | 1998-09-22 | — | — | US | disclosed |
| CN-1031053-C | Azaoxindole derivatives | PFIZER (US) | 1996-02-21 | — | — | CN | disclosed |
| CN-1053065-A | AZAOXINDOLE DERIVATIVES | PFIZER (US) | 1991-07-17 | — | — | CN | disclosed |
| WO-1991009598-A1 | AZAOXINDOLE DERIVATIVES | PFIZER INC. (US) | 1991-07-11 | — | — | WO | disclosed |
| EP-0436333-A2 | Azaoxindole derivatives | PFIZER INC. (US) | 1991-07-10 | — | — | EP | disclosed |