SCHEMBL8657398

SCHEMBL8657398

COc1cc(-c2c(F)c(F)c(F)c(F)c2NS(=O)(=O)c2ccccc2)cc(OC)c1C

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYTH2 Q99418 1/20 0.45
KAT6A Q92794 1/20 0.44
FFAR4 Q5NUL3 2/20 0.43
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
KDM4E B2RXH2 3/20 0.43
HSD17B10 Q99714 1/20 0.43
GAA P10253 1/20 0.43
PKM P14618 1/20 0.43
BRD1 O95696 1/20 0.42
BRPF1 P55201 1/20 0.42
BRPF3 Q9ULD4 1/20 0.42
CA12 O43570 1/20 0.42
CA9 Q16790 1/20 0.42
SLC40A1 Q9NP59 1/20 0.42
HPGD P15428 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
CYP17A1 P05093 1/20 0.42
TSHR P16473 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8659865 0.92 KAT6A (0.45) CYTH2KAT6AFFAR4MEN1KMT2A
SCHEMBL8657858 0.90 KDM4E (0.48) CYTH2KAT6AMEN1KMT2AKDM4E
SCHEMBL8657894 0.90 L3MBTL1 (0.44) CYTH2KAT6AMEN1KMT2AKDM4E
SCHEMBL8662798 0.88 CYTH2 (0.46) CYTH2KAT6AFFAR4MEN1KMT2A
SCHEMBL8659141 0.88 KAT6A (0.42) CYTH2KAT6AFFAR4MEN1KMT2A
SCHEMBL8658453 0.88 CA12 (0.51) MEN1KMT2AKDM4EGAAPKM
SCHEMBL8657954 0.87 AVPR2 (0.42) CYTH2KAT6AMEN1KMT2AKDM4E
SCHEMBL8660003 0.86 ALDH1A1 (0.49) KAT6AKMT2AKDM4EHPGDSMN1; SMN2
SCHEMBL8663489 0.85 CYTH2 (0.54) CYTH2KAT6AFFAR4MEN1KMT2A
SCHEMBL8661428 0.85 CYTH2 (0.54) CYTH2KAT6AFFAR4MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5739166-A ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT G.D. SEARLE & CO. (US) 1998-04-14 US disclosed