Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CALML3 | P27482 | 1/20 | 0.36 |
| ▸ | SDHA | P31040 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8653697 | 0.90 | ALDH1A1 (0.48) | MAPTALDH1A1KMT2AMAPK1TP53 | |
| SCHEMBL8654828 | 0.89 | ALDH1A1 (0.38) | MAPTALDH1A1KMT2ASYKHTT | |
| SCHEMBL8642619 | 0.89 | ALDH1A1 (0.38) | MAPTALDH1A1KMT2ASYKHTT | |
| SCHEMBL8655270 | 0.88 | ALDH1A1 (0.48) | MAPTALDH1A1KMT2AMEN1MAPK1 | |
| SCHEMBL8656943 | 0.86 | LMNA (0.47) | MAPTALDH1A1POLBLMNAMAOA | |
| SCHEMBL13855694 | 0.86 | GFER (0.44) | MAPTALDH1A1KMT2AHTTMEN1 | |
| SCHEMBL8642618 | 0.85 | F10 (0.44) | MAPTALDH1A1KMT2APOLBLMNA | |
| SCHEMBL8654163 | 0.85 | F10 (0.44) | MAPTALDH1A1KMT2APOLBLMNA | |
| SCHEMBL8643569 | 0.84 | CTSL (0.39) | ALDH1A1LMNAMAOAPTGS1MAOB | |
| SCHEMBL8656349 | 0.84 | MAOA (0.47) | MAPTALDH1A1KMT2ALMNAMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858453-A1 | 5-(ACETAMIDOMETHYL)-3-ARYLDIHYDROFURAN-2-ONE AND TETRAHYDROFURAN-2-ONE DERIVATIVES WITH ANTIBIOTIC ACTIVITY | AstraZeneca AB (SE) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997014690-A1 | 5-(ACETAMIDOMETHYL)-3-ARYLDIHYDROFURAN-2-ONE AND TETRAHYDROFURAN-2-ONE DERIVATIVES WITH ANTIBIOTIC ACTIVITY | ZENECA LIMITED (GB) | 1997-04-24 | — | — | WO | disclosed |