SCHEMBL5850195

SCHEMBL5850195

O=C1NCCSc2ccccc21

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RYR2 Q92736 2/20 0.55
ALDH1A1 P00352 3/20 0.53
MEN1 O00255 1/20 0.53
GAA P10253 1/20 0.53
KMT2A Q03164 1/20 0.53
PARP10 Q53GL7 6/20 0.48
PARP11 Q9NR21 6/20 0.48
PARP1 P09874 4/20 0.48
PDPK1 O15530 1/20 0.48
CA12 O43570 1/20 0.42
CA9 Q16790 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
HPGD P15428 4/20 0.41
NPSR1 Q6W5P4 1/20 0.41
S100A4 P26447 1/20 0.39
POLB P06746 1/20 0.39
MAPT P10636 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
ALOX15 P16050 1/20 0.38
MAPK10 P53779 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8658609 0.80 CA12 (0.45) RYR2ALDH1A1MEN1GAAKMT2A
SCHEMBL12849393 0.78 ALDH1A1 (0.46) RYR2ALDH1A1MEN1GAAKMT2A
SCHEMBL9635035 0.77 ALDH1A1 (0.53) RYR2ALDH1A1MEN1GAAKMT2A
SCHEMBL1238947 0.75 RYR2 (0.61) RYR2ALDH1A1MEN1GAAKMT2A
SCHEMBL1238521 0.75 PRKD1 (0.50) RYR2ALDH1A1MEN1GAAKMT2A
SCHEMBL9635151 0.75 PARP10 (0.50) RYR2ALDH1A1MEN1GAAKMT2A
SCHEMBL26942243 0.75 PARP10 (0.54) RYR2ALDH1A1MEN1GAAKMT2A
SCHEMBL30657972 0.75 PARP10 (0.54) RYR2ALDH1A1MEN1GAAKMT2A
SCHEMBL26653947 0.75 PARP10 (0.54) RYR2ALDH1A1MEN1GAAKMT2A
SCHEMBL14691900 0.75 PARP10 (0.50) RYR2ALDH1A1MEN1GAAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022057142-A1 STEROID SYNTHETASE INHIBITORS AND THERAPEUTIC USE THEREOF 广州中医药大学(广州中医药研究院) 2022-03-24 WO claimed
EP-4745139-A1 COMPOUND FOR TREATING AND PREVENTING RESPIRATORY SYNCYTIAL VIRUS INFECTION DISEASES CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. (CN) 2026-05-20 EP disclosed
CN-119285628-A Compounds for the treatment and prophylaxis of respiratory syncytial virus infection diseases 石药集团中奇制药技术(石家庄)有限公司 2025-01-10 CN disclosed
CN-118852149-A Compound for treating or preventing RSV virus diseases 石药集团中奇制药技术(石家庄)有限公司 2024-10-29 CN disclosed
US-20230399324-A1 AGENTS FOR TREATING DISORDERS INVOLVING RYANODINE RECEPTORS RYCARMA THERAPEUTICS, INC. 2023-12-14 US disclosed
US-20230399324-A1 AGENTS FOR TREATING DISORDERS INVOLVING RYANODINE RECEPTORS RYCARMA THERAPEUTICS, INC. 2023-12-14 US disclosed
EP-3782995-B1 SPIRO CONDENSED IMIDAZOLINE-2,4-DIONE DERIVATIVES AS HISTONE ACETYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF CANCER DISEASES SHANGHAI INST MATERIA MEDICA CAS (CN) 2023-11-22 EP disclosed
US-RE49481-E1 Compounds for the treatment and prophylaxis of respiratory syncytial virus disease HOFFMANN-LA ROCHE INC. (US) 2023-04-04 US disclosed
US-RE49481-E1 Compounds for the treatment and prophylaxis of respiratory syncytial virus disease HOFFMANN-LA ROCHE INC. (US) 2023-04-04 US disclosed
CN-110407769-B 3, 4-dihydro-benzo [ f ] [1,4] thiazepine-5 (2H) -one compounds and pharmaceutical use thereof 复旦大学 2022-11-08 CN disclosed
US-20090292119-A1 METHODS FOR SYNTHESIZING BENZOTHIAZEPINE COMPOUNDS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2009-11-26 US disclosed
US-20070098631-A2 DIAGNOSTIC COMPOUNDS COMPRISING A SCAFFOLD COUPLED TO A SIGNAL ENTITY FOR MEDICAL IMAGING DIAGNOSTIC GUERBET (FR) 2007-05-03 US disclosed
US-20070098631-A2 DIAGNOSTIC COMPOUNDS COMPRISING A SCAFFOLD COUPLED TO A SIGNAL ENTITY FOR MEDICAL IMAGING DIAGNOSTIC GUERBET (FR) 2007-05-03 US disclosed
US-7008938-B2 Benzene-fused heteroring derivatives and pharmaceutical agents comprising the same as active ingredient NOKIA CORPORATION (FI) 2006-03-07 US disclosed
US-20050009755-A1 Benzene-fused heteroring derivatives and pharmaceutical agents comprising the same as active ingredient ONO PHARMACEUTICAL CO., LTD. 2005-01-13 US disclosed
US-6809092-B2 1,3,4,5-TETRAHYDRO-2H-2-BENZAZEPIN-2-YL DERIVATIVES; CYSTEINE PROTEASE INHIBITORS ONO PHARMACEUTICAL CO., LTD. (JP) 2004-10-26 US disclosed
US-20030162964-A1 Benzene-fused heterocycle derivatives and drugs containing the same as the active ingredient NOKIA CORPORATION (FI) 2003-08-28 US disclosed
EP-1254898-A1 BENZENE-FUSED HETEROCYCLE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT ONO PHARMACEUTICAL CO., LTD. (JP) 2002-11-06 EP disclosed
EP-0368063-B1 PROCESS FOR THE CHLORINATION IN THE NUCLEUS OF AROMATIC HYDROCARBONS BAYER AG (DE) 1992-06-10 EP disclosed
US-4990707-A Process for the ring chlorination of aromatic hydrocarbons BAYER AKTIENGESELLSCHAFT (DE) 1991-02-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230399324-A1 AGENTS FOR TREATING DISORDERS INVOLVING RYANODINE RECEPTORS RYR2, RYR1, ATP2A1 RYR2 1/4885ALDH1A1 2677/4885MEN1 4283/4885
US-20070098631-A2 DIAGNOSTIC COMPOUNDS COMPRISING A SCAFFOLD COUPLED TO A SIGNAL ENTITY FOR MEDICAL IMAGING DIAGNOSTIC HTR3D, BRD4, CNR1 RYR2 57/4885ALDH1A1 639/4885MEN1 1323/4885
US-20090292119-A1 METHODS FOR SYNTHESIZING BENZOTHIAZEPINE COMPOUNDS KCNB2, KCNJ2, KCNJ5 RYR2 275/4885ALDH1A1 886/4885MEN1 2138/4885
US-20030162964-A1 Benzene-fused heterocycle derivatives and drugs containing the same as the active ingredient BACH1, BACE1, CMA1 RYR2 500/4885ALDH1A1 1884/4885MEN1 2086/4885
US-20050009755-A1 Benzene-fused heteroring derivatives and pharmaceutical agents comprising the same as active ingredient BACE1, BACE2, CBS RYR2 353/4885ALDH1A1 3625/4885MEN1 2782/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.