Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 5/20 | 0.50 |
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | EDNRB | P24530 | 1/20 | 0.47 |
| ▸ | EDNRA | P25101 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CCR4 | P51679 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046119 | 0.87 | FFAR4 (0.53) | ALDH1A1POLBKDM1AMAOAMEN1 | |
| SCHEMBL9047044 | 0.80 | EDNRA (0.71) | ALDH1A1HSD11B1KDM1AMAOAEDNRB | |
| SCHEMBL9046709 | 0.77 | ALDH1A1 (0.60) | ALDH1A1POLBHSD11B1KDM1AMAOA | |
| SCHEMBL9047067 | 0.75 | EDNRB (0.59) | ALDH1A1POLBHSD11B1KDM1AMAOA | |
| SCHEMBL9044830 | 0.75 | MAPT (0.53) | ALDH1A1L3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL9046378 | 0.73 | EDNRA (0.57) | ALDH1A1POLBHSD11B1KDM1AEDNRB | |
| SCHEMBL9045052 | 0.72 | MEN1 (0.55) | ALDH1A1KDM1AMAOAEDNRBEDNRA | |
| SCHEMBL8659102 | 0.72 | EDNRA (0.49) | ALDH1A1EDNRBEDNRAMEN1KMT2A | |
| SCHEMBL9045764 | 0.72 | EDNRB (0.59) | ALDH1A1POLBEDNRBEDNRAMEN1 | |
| SCHEMBL9495682 | 0.72 | EDNRB (0.59) | ALDH1A1POLBEDNRBEDNRAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |