SCHEMBL8659409

SCHEMBL8659409

COc1cc(OC)nc(Oc2ccc(N)c(O)c2C(=O)OC(C)[Si](C)(C)C)n1

nearest known ligand 0.49

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 2/20 0.39
CYP1A2 P05177 3/20 0.38
CYP2C9 P11712 3/20 0.38
CYP2C19 P33261 3/20 0.38
CYP3A4 P08684 2/20 0.38
ALDH1A1 P00352 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
ATM Q13315 1/20 0.38
GAA P10253 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8660857 0.83 TXNRD1 (0.38) NPSR1ALDH1A1
SCHEMBL8661354 0.83 NPSR1 (0.35) NPSR1CYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL9198250 0.82 CYP1A2 (0.45) NPSR1CYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL8671959 0.80 NPSR1 (0.36) NPSR1CYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL8659402 0.80 NPSR1 (0.38) NPSR1CYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL9195994 0.79 ALDH1A1 (0.57) NPSR1CYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL9156889 0.77 CYP1A2 (0.42) NPSR1CYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL8835981 0.75 NPSR1 (0.37) NPSR1CYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL8836395 0.74 NPSR1 (0.36) NPSR1CYP1A2CYP2C9CYP2C19CYP3A4
SCHEMBL8836380 0.74 NPSR1 (0.36) NPSR1CYP1A2CYP2C9CYP2C19CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5770544-A TRIAZINES KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1998-06-23 US disclosed
US-5616537-A Condensed heterocyclic derivatives and herbicides KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1997-04-01 US disclosed
EP-0606489-A1 CONDENSED HETEROCYCLIC DERIVATIVE AND WEEDKILLER KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1994-07-20 EP disclosed