SCHEMBL8660857

SCHEMBL8660857

COc1cc(OC)nc(Oc2ccc([N+](=O)[O-])c(O)c2C(=O)OC(C)[Si](C)(C)C)n1

nearest known ligand 0.54

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TXNRD1 Q16881 1/20 0.38
ALDH1A1 P00352 1/20 0.37
HTT P42858 1/20 0.37
NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8835513 0.85 TXNRD1 (0.35) TXNRD1
SCHEMBL8659071 0.84 TXNRD1 (0.34) TXNRD1NPSR1
SCHEMBL8659409 0.83 NPSR1 (0.39) ALDH1A1NPSR1
SCHEMBL8655744 0.81 TXNRD1 (0.36) TXNRD1ALDH1A1HTTNPSR1
SCHEMBL9198250 0.79 CYP1A2 (0.45) ALDH1A1NPSR1
SCHEMBL8671959 0.77 NPSR1 (0.36) ALDH1A1NPSR1
SCHEMBL9195994 0.76 ALDH1A1 (0.57) ALDH1A1NPSR1
SCHEMBL9156889 0.73 CYP1A2 (0.42) ALDH1A1NPSR1
SCHEMBL8835981 0.72 NPSR1 (0.37) ALDH1A1NPSR1
SCHEMBL8661354 0.72 NPSR1 (0.35) ALDH1A1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5770544-A TRIAZINES KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1998-06-23 US disclosed
US-5616537-A Condensed heterocyclic derivatives and herbicides KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1997-04-01 US disclosed
EP-0606489-A1 CONDENSED HETEROCYCLIC DERIVATIVE AND WEEDKILLER KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1994-07-20 EP disclosed