SCHEMBL8660339

SCHEMBL8660339

C=CCOC(=O)C(=C)CO.N#CC=CC=Cc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.39
MAPT P10636 4/20 0.39
RECQL P46063 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
LMNA P02545 2/20 0.38
MEN1 O00255 2/20 0.38
MAPK1 P28482 2/20 0.38
KMT2A Q03164 2/20 0.38
KDM4E B2RXH2 1/20 0.38
GAA P10253 1/20 0.38
MCL1 Q07820 2/20 0.38
PTP4A3 O75365 2/20 0.38
PTP4A1 Q93096 2/20 0.38
TSHR P16473 2/20 0.38
HSD17B10 Q99714 2/20 0.38
CASP1 P29466 1/20 0.37
CYP3A4 P08684 1/20 0.37
ALOX12 P18054 1/20 0.35
NPSR1 Q6W5P4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8847311 0.89 MAPT (0.41) ALDH1A1MAPTRECQLSMN1; SMN2TDP1
SCHEMBL11872611 0.87 MAPT (0.44) ALDH1A1MAPTRECQLSMN1; SMN2TDP1
SCHEMBL8818223 0.87 KMT2A (0.45) ALDH1A1MAPTSMN1; SMN2TDP1LMNA
Styrene SCHEMBL16395646 0.84 MAPT (0.44) ALDH1A1MAPTRECQLSMN1; SMN2TDP1
SCHEMBL170861 0.84 LMNA (0.42) ALDH1A1MAPTRECQLSMN1; SMN2TDP1
SCHEMBL6408239 0.83 MAPT (0.41) ALDH1A1MAPTRECQLSMN1; SMN2TDP1
SCHEMBL9547843 0.78 CASP1 (0.42) ALDH1A1MAPTRECQLSMN1; SMN2TDP1
SCHEMBL4559229 0.78 CASP1 (0.44) ALDH1A1MAPTRECQLSMN1; SMN2TDP1
SCHEMBL8660340 0.76 ALDH1A1 (0.43) ALDH1A1MAPTRECQLSMN1; SMN2TDP1
SCHEMBL11415162 0.76 PAM (0.47) ALDH1A1MAPTRECQLSMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1066763-C Resin compositions having excellent antistatic properties MITSUI CHEMICALS INC (JP) 2001-06-06 CN claimed
EP-0558264-B1 Low gloss polycarbonate/ABS blends GEN ELECTRIC (US) 1998-09-30 EP claimed
CN-1109078-A Resin compositions having excellent antistatic properties MITSUI TOATSU CHEMICALS (JP) 1995-09-27 CN claimed
EP-0558264-A1 Low gloss polycarbonate/ABS blends GENERAL ELECTRIC COMPANY (US) 1993-09-01 EP claimed
US-5236990-A Molding materials GENERAL ELECTRIC COMPANY (US) 1993-08-17 US claimed
CN-1066763-C Resin compositions having excellent antistatic properties MITSUI CHEMICALS INC (JP) 2001-06-06 CN disclosed
CN-1109078-A Resin compositions having excellent antistatic properties MITSUI TOATSU CHEMICALS (JP) 1995-09-27 CN disclosed