SCHEMBL8660435

SCHEMBL8660435

CC(=O)CC(Cl)c1ccc(C(C)C)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.42
USP5 P45974 1/20 0.42
CYP2C9 P11712 2/20 0.40
CYP2D6 P10635 1/20 0.40
HIF1A Q16665 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
TYR P14679 2/20 0.39
ALDH1A1 P00352 2/20 0.39
TDP1 Q9NUW8 1/20 0.39
SMN1; SMN2 Q16637 4/20 0.39
RAB9A P51151 3/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
FFAR1 O14842 1/20 0.39
KDM4E B2RXH2 1/20 0.39
MAPK1 P28482 1/20 0.39
HPGD P15428 1/20 0.39
MAPT P10636 1/20 0.38
HTT P42858 2/20 0.37
ACACB O00763 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5321358 0.88 BRD4 (0.50) POLBCYP2C9CYP2D6MEN1KMT2A
SCHEMBL4623899 0.84 ESR1 (0.46) CYP2C9CYP2D6HIF1AALDH1A1TDP1
SCHEMBL6935978 0.84 STAT3 (0.46) POLBL3MBTL1ALDH1A1TDP1SMN1; SMN2
SCHEMBL9033660 0.83 STAT3 (0.39) POLBALDH1A1TDP1SMN1; SMN2FFAR1
SCHEMBL9034467 0.83 FAAH (0.41) CYP2C9ALDH1A1SMN1; SMN2HTTACACB
SCHEMBL3822853 0.82 CYP1A2 (0.48) ALDH1A1SMN1; SMN2KMT2A
SCHEMBL3700232 0.82 LMNA (0.41) CYP2C9CYP2D6ALDH1A1RAB9AMEN1
SCHEMBL9034681 0.82 FAAH (0.42) CYP2C9ACACBLMNA
SCHEMBL9033570 0.82 STAT3 (0.38) ALDH1A1TDP1SMN1; SMN2FFAR1KDM4E
SCHEMBL4729080 0.82 ALDH1A1 (0.50) POLBCYP2C9CYP2D6ALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0871614-A1 ALPHA-(SUBSTITUTED ALKYLPHENYL)-4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINE BUTANOL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTI-HISTAMINES, ANTI-ALLERGY AGENTS AND BRONCHODILATORS HOECHST MARION ROUSSEL, INC. (US) 1998-10-21 EP disclosed
WO-1996035667-A1 ALPHA-(SUBSTITUTED ALKYLPHENYL)-4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINE BUTANOL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTI-HISTAMINES, ANTI-ALLERGY AGENTS AND BRONCHODILATORS Hoescht Marion Roussel, Inc. (US) 1996-11-14 WO disclosed
EP-0705245-A1 NOVEL INTERMEDIATES FOR THE PREPARATION OF ANTIHISTAMINIC 4-DIPHENYLMETHYL/DIPHENYLMETHOXY PIPERIDINE DERIVATIVES MERRELL PHARMACEUTICALS INC. (US) 1996-04-10 EP disclosed
WO-1995000480-A1 NOVEL INTERMEDIATES FOR THE PREPARATION OF ANTIHISTAMINIC 4-DIPHENYLMETHYL/DIPHENYLMETHOXY PIPERIDINE DERIVATIVES MERRELL PHARMACEUTICALS INC. (US) 1995-01-05 WO disclosed