SCHEMBL8660719

SCHEMBL8660719

O=C(Nc1ccccc1)C1(O)CC=Cc2ccccc21

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
LMNA P02545 3/20 0.38
TP53 P04637 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
EPHX1 P07099 1/20 0.38
TSHR P16473 1/20 0.38
EPHX2 P34913 1/20 0.38
CDK9 P50750 1/20 0.38
CLK4 Q9HAZ1 1/20 0.38
P2RX4 Q99571 1/20 0.38
NPSR1 Q6W5P4 1/20 0.37
NPC1 O15118 1/20 0.36
HPGD P15428 1/20 0.36
RAB9A P51151 1/20 0.36
SLC6A2 P23975 1/20 0.36
NAPRT Q6XQN6 1/20 0.36
HSD17B10 Q99714 1/20 0.36
ALDH1A1 P00352 1/20 0.36
POLB P06746 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18396414 0.82 MEN1 (0.50) MEN1KMT2ALMNASMN1; SMN2NPC1
SCHEMBL461337 0.81 THRB (0.40) NPSR1ALDH1A1TDP1HDAC4
SCHEMBL10586576 0.76 KDM4E (0.34) TDP1HDAC4
SCHEMBL5857537 0.76 LMNA (0.33) KMT2ALMNATSHRTDP1HDAC4
SCHEMBL29701281 0.76 KDM4E (0.34) TDP1HDAC4
SCHEMBL7109806 0.76 MAPT (0.39) MEN1KMT2ALMNASMN1; SMN2TSHR
SCHEMBL387970 0.73 L3MBTL1 (0.35) TP53SMN1; SMN2TSHRHPGDRAB9A
Oxalic Acid SCHEMBL29053840 0.71 THRB (0.36) NPSR1ALDH1A1TDP1HDAC4
SCHEMBL4346969 0.70 THRB (0.35) TDP1HDAC4
SCHEMBL8491987 0.70 TDP1 (0.35) MEN1KMT2AALDH1A1POLBTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0570973-B1 Color photographic materials and methods containing DIR or DIAR couplers and phenolic coupler solvents EASTMAN KODAK CO (US) 1998-11-18 EP disclosed
EP-0651288-B1 Photographic elements comprising 2-phenylcarbamoyl-1-naphthol image-modifying couplers yielding dyes resistant to crystallization and reduction EASTMAN KODAK CO (US) 1997-02-19 EP disclosed
US-5506094-A Photographic elements comprising 2-phenylcarbamoyl-1-naphthol image-modifying couplers yielding dyes resistant to crystallization and reduction EASTMAN KODAK COMPANY (US) 1996-04-09 US disclosed
US-5451496-A Color photographic materials and methods containing DIR or DIAR couplers and phenolic coupler solvents EASTMAN KODAK COMPANY (US) 1995-09-19 US disclosed
EP-0651288-A1 Photographic elements comprising 2-phenylcarbamoyl-1-naphthol image-modifying couplers yielding dyes resistant to crystallization and reduction EASTMAN KODAK COMPANY (US) 1995-05-03 EP disclosed
EP-0570973-A1 Color photographic materials and methods containing DIR or DIAR couplers and phenolic coupler solvents EASTMAN KODAK COMPANY (US) 1993-11-24 EP disclosed