SCHEMBL8660975

SCHEMBL8660975

Cc1ccc(Oc2ccc(Oc3c(C)cc(NC(=O)NC(=O)c4ccccc4Cl)c(C)c3Cl)cc2Cl)c(C)c1

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GCGR P47871 1/20 0.49
PYGL P06737 4/20 0.46
NPSR1 Q6W5P4 1/20 0.42
RAB9A P51151 2/20 0.41
PNLIP P16233 3/20 0.41
KMT2A Q03164 3/20 0.41
MAPT P10636 3/20 0.41
GAA P10253 2/20 0.41
ALDH1A1 P00352 2/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
MEN1 O00255 2/20 0.40
KDM4E B2RXH2 1/20 0.40
TDP1 Q9NUW8 1/20 0.39
NPC1 O15118 1/20 0.39
POLB P06746 1/20 0.39
PKM P14618 1/20 0.39
GHSR Q92847 1/20 0.38
PARG Q86W56 1/20 0.38
IDO1 P14902 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8658014 0.92 PYGL (0.52) GCGRPYGLNPSR1RAB9AKMT2A
SCHEMBL8657579 0.92 GCGR (0.47) GCGRPYGLNPSR1RAB9APNLIP
SCHEMBL9137470 0.88 GCGR (0.56) GCGRPYGLNPSR1PNLIPPARG
SCHEMBL8659386 0.87 NPSR1 (0.43) GCGRPYGLNPSR1PNLIPKMT2A
SCHEMBL8659541 0.86 ATM (0.44) PYGLNPSR1RAB9APNLIPKMT2A
SCHEMBL8661667 0.86 PYGL (0.49) GCGRPYGLNPSR1RAB9AKMT2A
SCHEMBL8663097 0.84 GCGR (0.55) GCGRPYGLNPSR1RAB9APNLIP
SCHEMBL10787570 0.84 GCGR (0.53) GCGRPYGLRAB9APNLIPKMT2A
SCHEMBL8657665 0.84 PYGL (0.49) GCGRPYGLNPSR1RAB9AKMT2A
SCHEMBL8656199 0.83 MEN1 (0.42) GCGRNPSR1KMT2AMAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5776981-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5776982-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5420163-A Insecticides or miticides CIBA-GEIGY (US) 1995-05-30 US disclosed
US-5135953-A Oral or injections; cattle, swine, poultry CIBA-GEIGY (US) 1992-08-04 US disclosed
EP-0211004-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS RHONE-POULENC NEDERLAND B.V. (NL) 1987-02-25 EP disclosed
US-4602109-A Novel pesticidal phenoxyphenyl and phenoxypyridyl benzoyl ureas and process for preparation UNION CARBIDE CORPORATION (US) 1986-07-22 US disclosed
WO-1986003941-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS UNION CARBIDE CORPORATION (US) 1986-07-17 WO disclosed
US-4540578-A Pesticidal phenoxypyridyl benzoyl ureas UNION CARBIDE CORPORATION (US) 1985-09-10 US disclosed
EP-0113247-A1 Pesticidal phenoxyphenyl and phenoxypyridyl benzoyl ureas and process for their preparation UNION CARBIDE CORPORATION (US) 1984-07-11 EP disclosed