Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 6/20 | 0.33 |
| ▸ | TK2 | O00142 | 1/20 | 0.32 |
| ▸ | SLC6A1 | P30531 | 3/20 | 0.31 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8661016 | 0.82 | MAPT (0.41) | CHRM3CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL8660036 | 0.81 | RIPK1 (0.34) | CHRM3SLC6A1SLC6A11ALOX5 | |
| SCHEMBL8659950 | 0.74 | L3MBTL1 (0.32) | CHRM3CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL8660376 | 0.73 | RIPK1 (0.37) | CHRM3SLC6A1SLC6A11CHRM2CHRM4 | |
| SCHEMBL6858149 | 0.72 | OPRK1 (0.38) | CHRM3CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL8661346 | 0.71 | RIPK1 (0.31) | ALDH1A1 | |
| SCHEMBL8662712 | 0.71 | RIPK1 (0.38) | — | |
| SCHEMBL8662095 | 0.71 | PIK3CD (0.40) | — | |
| SCHEMBL8659654 | 0.71 | RIPK1 (0.36) | SLC6A1SLC6A11ALDH1A1 | |
| SCHEMBL8661543 | 0.70 | MEN1 (0.31) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5714606-A | OLIGONUCLEOTIDE HAVING RECEPTOR BINDING SITES; ENZYME INHIBITORS, ANTIINFLAMMATORY AGENTS, MEDICAL DIAGNOSIS | ISIS PHARMACEUTICALS, INC. (US) | 1998-02-03 | — | — | US | disclosed |
| EP-0739335-A4 | PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS INC (US) | 1997-04-02 | — | — | EP | disclosed |
| EP-0739335-A1 | PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS, INC. (US) | 1996-10-30 | — | — | EP | disclosed |
| WO-1995018792-A1 | PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS, INC. (US) | 1995-07-13 | — | — | WO | disclosed |