Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | BCL9 | O00512 | 1/20 | 0.51 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL409598 | 0.86 | HTR2A (0.59) | HTR2ABCL9CTNNB1MAPTGAA | |
| SCHEMBL8900906 | 0.86 | BCL9 (0.63) | HTR2ABCL9CTNNB1MAPTGAA | |
| SCHEMBL13033879 | 0.85 | HTR2A (0.56) | HTR2ABCL9CTNNB1MAPTGAA | |
| SCHEMBL2597400 | 0.84 | BCL9 (0.63) | HTR2ABCL9CTNNB1MAPTGAA | |
| SCHEMBL763025 | 0.83 | HTR2A (0.57) | HTR2ABCL9CTNNB1MAPTGAA | |
| SCHEMBL13033882 | 0.83 | HTR2A (0.61) | HTR2AMAPTCRHBPCRHR2L3MBTL1 | |
| SCHEMBL1144551 | 0.82 | MGLL (0.62) | HTR2ABCL9CTNNB1MAPTGAA | |
| SCHEMBL409084 | 0.82 | HTR2A (0.56) | HTR2ABCL9CTNNB1MAPTGAA | |
| Hydrochloric Acid SCHEMBL30544551 | 0.82 | BCL9 (0.61) | HTR2ABCL9CTNNB1MAPTGAA | |
| SCHEMBL4433836 | 0.82 | HTR2A (0.56) | HTR2ABCL9CTNNB1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5807688-A | ANTIBODY DIRECTED ANZYME PRODRUG THERAPY | ZENECA LIMITED (GB) | 1998-09-15 | — | — | US | disclosed |
| EP-0745673-A2 | Catalytic antibody regulated prodrug therapy | ZENECA LIMITED (GB) | 1996-12-04 | — | — | EP | disclosed |