SCHEMBL8664029

SCHEMBL8664029

N#Cc1cc(SC(F)(F)F)[nH]c1-c1ccc(Cl)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 3/20 0.43
ALDH1A1 P00352 7/20 0.39
KDM4E B2RXH2 6/20 0.39
HPGD P15428 3/20 0.39
GAA P10253 2/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
LMNA P02545 1/20 0.39
GLA P06280 1/20 0.39
CRHBP P24387 1/20 0.39
HTT P42858 1/20 0.39
CRHR2 Q13324 1/20 0.39
MCL1 Q07820 1/20 0.38
MAOA P21397 5/20 0.36
MAOB P27338 5/20 0.36
CYP1A2 P05177 2/20 0.34
CYP2C9 P11712 2/20 0.34
CYP2C19 P33261 2/20 0.34
CYP3A4 P08684 1/20 0.34
CYP11B1 P15538 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7782881 0.79 MAOA (0.51) ALDH1A1KDM4EHPGDGAAMEN1
SCHEMBL3893100 0.79 KDM4E (0.46) ARALDH1A1KDM4EHPGDGAA
SCHEMBL8662133 0.78 GCGR (0.37) ALDH1A1KDM4EHPGDGAAMEN1
Bromide SCHEMBL29618239 0.78 KDM4E (0.45) ARALDH1A1KDM4EHPGDGAA
SCHEMBL9567328 0.77 ALDH1A1 (0.41) ARALDH1A1KDM4EHPGDGAA
SCHEMBL7782891 0.76 ALDH1A1 (0.52) ALDH1A1KDM4EHPGDGAAMEN1
SCHEMBL7784410 0.75 MAOA (0.43) ALDH1A1KDM4EHPGDGAAMEN1
SCHEMBL9221279 0.75 MCL1 (0.46) ALDH1A1KDM4EHPGDGAAMEN1
SCHEMBL7782943 0.74 MAOA (0.46) ALDH1A1KDM4EHPGDGAAMEN1
SCHEMBL9219554 0.73 MCL1 (0.45) ALDH1A1KDM4EHPGDGAAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5484807-A Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents BASF AKTIENGESELLSCHAFT 1996-01-16 US claimed
US-5739155-A Haloalkylthio,-sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents AMERICAN CYANAMID CO. (US) 1998-04-14 US disclosed
EP-0549866-B1 Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal, acaricidal and fungicidal agents AMERICAN CYANAMID CO (US) 1997-08-13 EP disclosed
US-5484807-A Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents BASF AKTIENGESELLSCHAFT 1996-01-16 US disclosed
US-5468877-A FOR PROTECTING CROPS AMERICAN CYANAMID COMPANY (US) 1995-11-21 US disclosed
US-5306827-A Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents AMERICAN CYANAMID COMPANY (US) 1994-04-26 US disclosed
US-5284863-A Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole fungicidal agents AMERICAN CYANAMID COMPANY (US) 1994-02-08 US disclosed
EP-0549866-A1 Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal, acaricidal and fungicidal agents AMERICAN CYANAMID COMPANY (US) 1993-07-07 EP disclosed