Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.38 |
| ▸ | ITGAV | P06756 | 2/20 | 0.38 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.38 |
| ▸ | BCL2 | P10415 | 2/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601202 | 0.91 | S1PR1 (0.39) | THRATHRBS1PR1S1PR3MCL1 | |
| SCHEMBL6599833 | 0.85 | PLA2G2A (0.47) | THRATHRBS1PR1MCL1 | |
| SCHEMBL6598794 | 0.84 | PLA2G2A (0.47) | THRATHRBS1PR1S1PR3 | |
| SCHEMBL6598798 | 0.83 | PLA2G2A (0.57) | — | |
| SCHEMBL3504371 | 0.83 | S1PR1 (0.44) | S1PR1S1PR3 | |
| SCHEMBL6598501 | 0.80 | PLA2G2A (0.38) | THRATHRBS1PR1S1PR3 | |
| SCHEMBL6598919 | 0.79 | S1PR1 (0.36) | THRATHRBS1PR1S1PR3 | |
| SCHEMBL6598918 | 0.79 | S1PR1 (0.36) | THRATHRBS1PR1S1PR3 | |
| SCHEMBL8624729 | 0.78 | THRA (0.46) | THRATHRB | |
| SCHEMBL6599901 | 0.78 | S1PR1 (0.39) | S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880519-A1 | THIAZOLYLBENZOFURAN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997027190-A1 | THIAZOLYLBENZOFURAN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-31 | — | — | WO | disclosed |