SCHEMBL8665346

SCHEMBL8665346

Cc1c(Cl)cccc1NC(=O)c1nccc(C(=O)O)c1C(=O)O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.54
KDM4E B2RXH2 2/20 0.54
MAPT P10636 4/20 0.53
DHODH Q02127 1/20 0.53
KMT2A Q03164 4/20 0.50
CYP1A2 P05177 2/20 0.50
CYP3A4 P08684 2/20 0.50
CYP2C9 P11712 2/20 0.50
CYP2C19 P33261 2/20 0.50
MEN1 O00255 1/20 0.50
USP2 O75604 1/20 0.50
MT-CO2 P00403 1/20 0.50
LMNA P02545 1/20 0.50
TTR P02766 1/20 0.50
PLA2G1B P04054 1/20 0.50
PGR P06401 1/20 0.50
HTR1A P08908 1/20 0.50
ADRA2A P08913 1/20 0.50
ADORA3 P0DMS8 1/20 0.50
AR P10275 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8664992 0.85 ALDH1A1 (0.67) ALDH1A1KDM4EMAPTDHODHKMT2A
SCHEMBL8901777 0.80 ALDH1A1 (0.79) ALDH1A1KDM4EMAPTDHODHKMT2A
SCHEMBL7825161 0.76 MAPT (0.68) ALDH1A1KDM4EMAPTDHODHKMT2A
SCHEMBL7824641 0.75 MAPT (0.63) ALDH1A1KDM4EMAPTKMT2ACYP1A2
SCHEMBL8664634 0.74 KDM4E (0.62) ALDH1A1KDM4EMAPTDHODHKMT2A
SCHEMBL28442197 0.73 NPC1 (0.76) ALDH1A1MAPTKMT2ARXFP1RAB9A
SCHEMBL2093177 0.72 MAPT (0.71) ALDH1A1KDM4EMAPTKMT2ACYP1A2
Iodide SCHEMBL30758631 0.70 MAPT (0.84) ALDH1A1KDM4EMAPTKMT2ACYP1A2
SCHEMBL24518495 0.70 DHODH (0.65) MAPTDHODHKMT2ACYP1A2CYP3A4
SCHEMBL30614598 0.70 DHODH (0.65) MAPTDHODHKMT2ACYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5843868-A Pryidine-2,3-dicarboxylic acid diamide derivatives and herbicides comprising said derivatives as active ingredient NIHON NOHYAKU CO., LTD. (JP) 1998-12-01 US disclosed
EP-0799825-A1 Pyridine-2,3-dicarboxylic acid diamide derivatives and herbicides comprising said derivatives as active ingredient NIHON NOHYAKU CO., LTD. (JP) 1997-10-08 EP disclosed