Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHAT | P28329 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3260115 | 0.78 | KDM4A (0.57) | RAB9AKDM4EMEN1NPC1KMT2A | |
| SCHEMBL8359207 | 0.77 | CHAT (0.60) | CHATRAB9AAPOBEC3AAPOBEC3GKDM4E | |
| SCHEMBL2845206 | 0.75 | RELA (0.55) | CHATAPP | |
| SCHEMBL2845201 | 0.75 | RELA (0.55) | CHATAPP | |
| SCHEMBL29808641 | 0.73 | RELA (0.53) | CHATAPP | |
| SCHEMBL29523356 | 0.73 | GSK3B (0.44) | KDM4EAPP | |
| SCHEMBL2776332 | 0.71 | APP (0.67) | RAB9AKDM4EMEN1NPC1KMT2A | |
| SCHEMBL2776337 | 0.71 | APP (0.67) | RAB9AKDM4EMEN1NPC1KMT2A | |
| Hydrochloric Acid SCHEMBL9052352 | 0.70 | CHAT (0.38) | CHATRAB9AAPOBEC3AAPOBEC3GKDM4E | |
| SCHEMBL4072573 | 0.69 | MAPT (0.55) | RAB9AKDM4EMEN1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763066-A | Nonlinear optical inclusion complexes | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 1998-06-09 | — | — | US | disclosed |