Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHAT | P28329 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HBB | P68871 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8359207 | 0.79 | CHAT (0.60) | CHATRAB9AAPOBEC3AAPOBEC3GKDM4E | |
| SCHEMBL2845206 | 0.76 | RELA (0.55) | CHATAPPRELA | |
| SCHEMBL2845201 | 0.76 | RELA (0.55) | CHATAPPRELA | |
| SCHEMBL29808641 | 0.74 | RELA (0.53) | CHATAPPRELA | |
| SCHEMBL29523356 | 0.74 | GSK3B (0.44) | KDM4EAPPMAPTGAARELA | |
| SCHEMBL4072573 | 0.73 | MAPT (0.55) | RAB9AKDM4EAPPMEN1KMT2A | |
| SCHEMBL2776332 | 0.72 | APP (0.67) | RAB9AKDM4EAPPRAD52MEN1 | |
| SCHEMBL2776337 | 0.72 | APP (0.67) | RAB9AKDM4EAPPRAD52MEN1 | |
| Bromide SCHEMBL8666503 | 0.70 | CHAT (0.40) | CHATRAB9AAPOBEC3AAPOBEC3GKDM4E | |
| SCHEMBL5369580 | 0.65 | GSK3B (0.41) | RAB9AKDM4EAPPMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996041173-A1 | NANOPARTICLES IMPRINTED WITH RECOGNITION SITES FOR TARGET MOLECULES | MARTINEX R & D INC. (CA) | 1996-12-19 | — | — | WO | disclosed |