Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 2/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8666696 | 0.79 | AVPR1A (0.41) | DHODHPTGS2 | |
| SCHEMBL4879887 | 0.75 | COMT (0.49) | COMTHPGDSDHODHKMT2APDE3B | |
| SCHEMBL8666901 | 0.75 | PTGS2 (0.42) | DHODHKMT2APTGS2PDE3BPDE3A | |
| SCHEMBL8669626 | 0.73 | MAP4K4 (0.48) | COMTHPGDSDHODHKMT2APDE3B | |
| SCHEMBL2225245 | 0.71 | HPGDS (0.50) | COMTHPGDSDHODHKMT2APDE3B | |
| SCHEMBL13843725 | 0.71 | HPGDS (0.53) | COMTHPGDSPDE3BPDE3AHSD11B1 | |
| SCHEMBL14190000 | 0.70 | HPGDS (0.49) | COMTHPGDSDHODHKMT2APDE3B | |
| SCHEMBL8666893 | 0.70 | PTGS2 (0.39) | DHODHKMT2APTGS2 | |
| SCHEMBL6547472 | 0.69 | CYP11B1 (0.50) | COMTHPGDSDHODHKMT2APDE3B | |
| SCHEMBL11623042 | 0.68 | HPGDS (0.50) | COMTHPGDSPTGS2PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811445-A | ANGIOTENSIN II INHIBITORS | ROUSSEL UCLAF (FR) | 1998-09-22 | — | — | US | disclosed |