Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.51 |
| ▸ | GBA1 | P04062 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MMP12 | P39900 | 1/20 | 0.51 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.50 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | MMP7 | P09237 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL760439 | 0.85 | MMP1 (0.67) | MMP1GAAMMP12MMP2MMP3 | |
| Aspartic Acid SCHEMBL10590014 | 0.81 | KDM4E (0.47) | SLC1A3SLC1A2SLC1A1SMN1; SMN2ALDH1A1 | |
| Aspartic Acid SCHEMBL10590016 | 0.81 | KDM4E (0.47) | SLC1A3SLC1A2SLC1A1SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6739604 | 0.80 | GBA1 (0.65) | MMP1GBA1SLC1A3SLC1A2SLC1A1 | |
| Hydrochloric Acid SCHEMBL6739598 | 0.80 | GBA1 (0.65) | MMP1GBA1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL1664363 | 0.79 | LARS1 (0.59) | MMP1GBA1GAASLC1A3SLC1A2 | |
| SCHEMBL8023841 | 0.79 | GBA1 (0.55) | GBA1SLC1A3SLC1A2SLC1A1ALDH1A1 | |
| SCHEMBL7329249 | 0.79 | GBA1 (0.63) | GBA1SLC1A3SLC1A2SLC1A1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8567005 | 0.78 | GBA1 (0.54) | GBA1SLC1A3SLC1A2SLC1A1ALDH1A1 | |
| SCHEMBL8451097 | 0.77 | MMP9 (0.57) | MMP1GAAMMP12MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691986-B1 | NOVEL PROCESSES AND INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF PLATELET CLYCOPROTEIN IIb/IIIa INHIBITORS | DU PONT MERCK PHARMA (US) | 1998-12-02 | — | — | EP | disclosed |
| US-5817749-A | CYCLIC PENTAPEPTIDES | DUPONT PHARMACEUTICALS COMPANY (US) | 1998-10-06 | — | — | US | disclosed |
| EP-0691986-A1 | NOVEL PROCESSES AND INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF PLATELET CLYCOPROTEIN IIb/IIIa INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994022909-A1 | NOVEL PROCESSES AND INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF PLATELET CLYCOPROTEIN IIb/IIIa INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-10-13 | — | — | WO | disclosed |