SCHEMBL866726

SCHEMBL866726

Nc1ccccc1Sc1cc(Sc2ccccc2N)c([N+](=O)[O-])cc1Cl

nearest known ligand 0.86

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PDE7A Q13946 12/20 0.86
SMN1; SMN2 Q16637 1/20 0.65
MAPT P10636 4/20 0.58
LMNA P02545 3/20 0.58
POLB P06746 1/20 0.56
L3MBTL1 Q9Y468 1/20 0.56
SLC6A4 P31645 2/20 0.56
KDM4E B2RXH2 2/20 0.51
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
PDE7B Q9NP56 3/20 0.48
ALDH1A1 P00352 1/20 0.46
GLA P06280 1/20 0.46
TDP1 Q9NUW8 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30605799 1.00 PDE7A (0.86) PDE7ASMN1; SMN2MAPTLMNAPOLB
SCHEMBL7607819 0.82 PDE7A (1.00) PDE7ASMN1; SMN2MAPTLMNAPOLB
SCHEMBL3357437 0.82 PDE7A (0.58) PDE7ASMN1; SMN2MAPTLMNAPOLB
SCHEMBL8095611 0.79 PDE7A (1.00) PDE7ASMN1; SMN2MAPTLMNAPOLB
SCHEMBL1455439 0.79 PDE7A (0.74) PDE7ASMN1; SMN2MAPTLMNAPOLB
SCHEMBL11422901 0.77 PDE7A (0.63) PDE7ASMN1; SMN2MAPTSLC6A4MEN1
SCHEMBL2964985 0.77 PDE7A (0.70) PDE7ASMN1; SMN2MAPTLMNAPOLB
SCHEMBL19745705 0.77 PDE7A (0.70) PDE7ASMN1; SMN2MAPTLMNAPOLB
SCHEMBL11248729 0.77 PDE7A (0.58) PDE7ASMN1; SMN2MAPTSLC6A4MEN1
SCHEMBL5833050 0.73 SLC6A4 (0.76) PDE7ASLC6A4TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250180952-A1 PHOTOALIGNING MATERIALS Rolic Technologies AG (CH) 2025-06-05 US disclosed
WO-2023174773-A1 PHOTOALIGNING MATERIALS Rolic Technologies AG (CH) 2023-09-21 WO disclosed
US-11634544-B2 Photoaligning materials Rolic Technologies AG (CH) 2023-04-25 US disclosed
US-20210340330-A1 PHOTOALIGNING MATERIALS Rolic Technologies AG (CH) 2021-11-04 US disclosed
US-20200223984-A1 PHOTOALIGNING MATERIALS Rolic Technologies AG (CH) 2020-07-16 US disclosed
US-10696795-B2 Photoaligning materials Rolic Technologies AG (CH) 2020-06-30 US disclosed
EP-3374467-B1 COMPOSITIONS OF PHOTO-ALIGNABLE MATERIALS ROLIC TECH AG (CH) 2020-04-15 EP disclosed
US-10558089-B2 Photoalignment composition ROLIC AG (CH) 2020-02-11 US disclosed
EP-2222815-B1 PHOTOALIGNMENT COMPOSITION ROLIC TECH AG (CH) 2019-05-29 EP disclosed
US-10208031-B2 Photocrosslinkable materials comprising alicyclic group ROLIC AG (CH) 2019-02-19 US disclosed
US-20120076952-A1 PHOTOCROSSLINKABLE MATERIALS ROLIC AG (CH) 2012-03-29 US disclosed
EP-2308827-A1 Photocrosslinkable materials Rolic AG (CH) 2011-04-13 EP disclosed
EP-2308826-A1 Photocrosslinkable materials Rolic AG (CH) 2011-04-13 EP disclosed
EP-2305632-A1 Photocrosslinkable materials Rolic AG (CH) 2011-04-06 EP disclosed
EP-2305631-A1 Photocrosslinkable materials Rolic AG (CH) 2011-04-06 EP disclosed
US-20100266814-A1 PHOTOALIGNMENT COMPOSITION ROLIC AG (CH) 2010-10-21 US disclosed
US-20100048849-A1 PHOTOCROSSLINKABLE MATERIALS COMPRISING ALICYCLIC GROUP ROLIC AG (CH) 2010-02-25 US disclosed
US-20080293888-A1 Photocrosslinkable Materials ROLIC AG (CH) 2008-11-27 US disclosed
EP-1966119-A1 PHOTOCROSSLINKABLE MATERIALS Rolic AG (CH) 2008-09-10 EP disclosed
WO-2007071091-A1 PHOTOCROSSLINKABLE MATERIALS ROLIC AG (CH) 2007-06-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10208031-B2 Photocrosslinkable materials comprising alicyclic group DDC, ALAD, DYNC1LI1 PDE7A 3970/4885SMN1; SMN2 2470/4885MAPT 1424/4885
US-20100048849-A1 PHOTOCROSSLINKABLE MATERIALS COMPRISING ALICYCLIC GROUP DDC, ALAD, DYNC1LI1 PDE7A 3970/4885SMN1; SMN2 2470/4885MAPT 1424/4885
US-20080293888-A1 Photocrosslinkable Materials DDC, PARG, ALAD PDE7A 3997/4885SMN1; SMN2 1478/4885MAPT 295/4885
US-20120076952-A1 PHOTOCROSSLINKABLE MATERIALS DDC, PARG, ALAD PDE7A 3997/4885SMN1; SMN2 1478/4885MAPT 295/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.