Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 3/20 | 0.36 |
| ▸ | HEXA | P06865 | 2/20 | 0.36 |
| ▸ | HEXB | P07686 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13064098 | 0.84 | SELE (0.35) | SELEVCAM1 | |
| SCHEMBL16712847 | 0.78 | RPS6KB1 (0.30) | RPS6KB1 | |
| SCHEMBL28518966 | 0.78 | AHCY (0.33) | ADORA2AADORA1ADORA2B | |
| SCHEMBL3641399 | 0.77 | SELE (0.40) | ALDH1A1LMNAPDE4DSMN1; SMN2SELE | |
| SCHEMBL30828905 | 0.76 | SELE (0.32) | SELEVCAM1 | |
| SCHEMBL16712851 | 0.76 | SELE (0.32) | SELEVCAM1 | |
| SCHEMBL12323407 | 0.76 | NOS2 (0.45) | DHFRADORA2AADORA1PI4KAPI4K2B | |
| SCHEMBL8718664 | 0.76 | SELE (0.32) | SELEVCAM1 | |
| SCHEMBL15155111 | 0.75 | RPS6KB1 (0.32) | RPS6KB1 | |
| SCHEMBL8491244 | 0.74 | SELE (0.31) | SELEVCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702355-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS CONTAINING PYRIMIDINE, THE PREPARATION AND APPLICATION THEREOF | SHENYANG SINOCHEM AGROCHEMICALS R & D CO LTD (CN) | 2022-01-12 | — | — | EP | disclosed |
| EP-2913325-B1 | SUBSTITUTED PYRIMIDINE COMPOUND AND USES THEREOF | SHENYANG SINOCHEM AGROCHEMICALS R & D CO LTD (CN) | 2021-04-21 | — | — | EP | disclosed |
| EP-3299366-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS CONTAINING PYRIMIDINE AND PREPARATION METHOD AND USE THEREOF AS PESTICIDES | SHENYANG SINOCHEM AGROCHEMICALS R & D CO LTD (CN) | 2020-09-09 | — | — | EP | disclosed |
| EP-3702355-A1 | SUBSTITUTED PYRAZOLE COMPOUNDS CONTAINING PYRIMIDINE, THE PREPARATION AND APPLICATION THEREOF | Shenyang Sinochem Agrochemicals R&D Co., Ltd. (CN) | 2020-09-02 | — | — | EP | disclosed |
| EP-3299366-A1 | SUBSTITUTED PYRAZOLE COMPOUNDS CONTAINING PYRIMIDINE AND PREPARATION METHOD AND USE THEREOF | Shenyang Sinochem Agrochemicals R & D Co., Ltd. (CN) | 2018-03-28 | — | — | EP | disclosed |
| WO-2015068773-A1 | NITROGEN-CONTAINING SATURATED HETEROCYCLIC COMPOUND | 石原産業株式会社 | 2015-05-14 | — | — | WO | disclosed |
| EP-0880505-A1 | ACYLATED 4-AMINO- AND 4-HYDRAZINOPYRIMIDINES AND THEIR USE AS PESTICIDES | BAYER AG (DE) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028133-A1 | ACYLATED 4-AMINO- AND 4-HYDRAZINOPYRIMIDINES AND THEIR USE AS PESTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-08-07 | — | — | WO | disclosed |
| EP-0370391-B1 | Process for the preparation of 4,5-dichloro-6-ethyl pyrimidine | LONZA AG (CH) | 1994-11-02 | — | — | EP | disclosed |
| US-4977264-A | Condensing 2-chloro-3-oxo-pentanoic acid ester with formamidinium salt, reacting with phosphoryl chloride | LONZA LTD. (CH) | 1990-12-11 | — | — | US | disclosed |
| EP-0370391-A2 | Process for the preparation of 4,5-dichloro-6-ethyl pyrimidine | LONZA AG (CH) | 1990-05-30 | — | — | EP | disclosed |